Division of Translational Surgical Oncology, National Center for Tumor Diseases (NCT) Dresden, 01307, Dresden, Germany.
German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Sci Rep. 2020 Jul 16;10(1):11849. doi: 10.1038/s41598-020-68886-3.
Anatomically realistic organ replicas or phantoms allow for accurate studies and reproducible research. To recreate a human kidney, mimicry of the elastic properties of the human kidney is crucial. However, none of the related work addressed the design and development of a kidney phantom using only silicone as material. In contrast to paraffin and hydrogel, silicone is an ideal variant for its extended shelf life, soft-tissue-like feeling, and viscoelastic modularity. To this end, we conducted Uniaxial Compression testing and Cauchy stress modeling. Results indicate that none of the available manufacturer silicone brands are suitable for the task of creating a realistic kidney phantom. Indeed, the tested silicone mixtures in low and high strain fall outside the required approximate target compressive moduli of 20 kPa and 500 kPa, respectively. This work provides a frame of reference for future work by avoiding the pitfalls of the selected ready-made silicones and reusing the reported theoretical and experimental setup to design a realistic replica of the kidney organ.
解剖学逼真的器官复制品或体模允许进行准确的研究和可重复的研究。为了重建人类肾脏，模仿人类肾脏的弹性特性至关重要。然而，没有任何相关工作涉及仅使用硅酮作为材料设计和开发肾脏体模。与石蜡和水凝胶相比，硅酮是一种理想的变体，因为它具有延长的保质期、软组织般的感觉和粘弹性模块性。为此，我们进行了单轴压缩测试和柯西应力建模。结果表明，没有一种现有的制造商硅酮品牌适合创建逼真的肾脏体模的任务。事实上，在所测试的低应变和高应变速率下，测试的硅酮混合物都不符合分别需要的大约 20 kPa 和 500 kPa 的目标压缩模量。这项工作通过避免选择的现成硅酮的陷阱，并重新使用报告的理论和实验设置来设计肾脏器官的逼真复制品，为未来的工作提供了参考。
