Comparison of the Effects of Photobiomodulation with Different Lasers on Orthodontic Movement and Reduction of the Treatment Time with Fixed Appliances in Novel Scientific Reports: A Systematic Review with Meta-Analysis.

The duration of orthodontic treatment is one of the most important aspects considered by patients. Photobiomodulation (PBM) depends upon the exposure of the tissue to particular, therapeutic wavelengths of light in the "therapeutic window" (from 600 to 1200 nm). PBM increases cell metabolism, which leads to higher ATP production. Increasing the amount of ATP in well-vascularized bone cells promotes cell proliferation and differentiation, creating a favorable environment for tooth movement. The aim of the study is to discuss and compare the use of PBM in accelerating the orthodontic movement and reducing the time of treatment. A systematic review was conducted. Literature searches were performed using Medline (PubMed), Web of Science, and Scopus (from September 13 to September 20, 2019). The quality assessment was performed using the Jadad scale for reporting randomized controlled trials for randomized clinical trial and randomized control clinical trial studies, and the Newcastle/Ottawa Quality Assessment Form for case/control studies. Thirty-three articles from PubMed, 46 from Scopus, 5 from Web of Science were selected. After removal of duplicates, 82 articles were analyzed. Subsequently, 74 articles were excluded because they did not meet the inclusion criteria. The remaining eight articles were included in the qualitative synthesis. PBM is an efficient, effective, and noninvasive method to accelerate orthodontic tooth movement. PBM should be introduced into the daily practice of treating various malocclusions as an additional procedure. Intraoral application gives better results and its introduction to treatment seems more reasonable.