Institute of Pharmaceutical Research, GLA University, Mathura -281406, India.
Curr Drug Deliv. 2020;17(10):911-924. doi: 10.2174/1567201817666200717090623.
Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective drug delivery system. The delivery systems employing the use of polymers, such as chitosan and pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an increased amount of the drug to reach the target tissue or cells. In this systematic review of published literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the use of chitosan and pectin in colon targeted drug delivery systems.
结肠癌是最常见的疾病之一，传统化疗在其治疗中并未被证明有效。它在所有年龄段的所有癌症导致的死亡率中排名第二。缺乏选择性和生物分布不良是开发用于治疗结肠癌的潜在治疗剂的最大挑战。纳米粒子作为一种有效的药物递送系统具有巨大的前景。使用聚合物（如壳聚糖和果胶）作为载体分子的递送系统可确保药物的最大吸收，减少不必要的副作用，并为治疗剂提供保护，防止其快速清除或降解，从而使更多的药物能够到达目标组织或细胞。在对已发表文献的系统综述中，作者旨在评估壳聚糖和果胶作为聚合物载体在结肠癌治疗中用于结肠靶向药物递送的作用。本综述总结了使用壳聚糖和果胶在结肠靶向药物递送系统中的各种研究。
