Ministry of Agricultural and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, College of Agriculture & Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Ministry of Agricultural and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, College of Agriculture & Biotechnology, Zhejiang University, Hangzhou, 310058, China; College of Life Sciences and Resource Environment, Key Laboratory of Crop Growth and Development Regulation of Jiangxi Province, Yichun University, Yichun, 336000, China.
Microb Pathog. 2020 Oct;147:104391. doi: 10.1016/j.micpath.2020.104391. Epub 2020 Jul 14.
Mosquitoes are the main vector of multiple diseases worldwide and transmit viral (malaria, chikungunya, encephalitis, yellow fever, as well as dengue fever), as well as bacterial diseases (tularemia). To manage the outbreak of mosquito populations, various management programs include the application of chemicals, followed by biological and genetic control. Here we aimed to focus on the role of bacterial pathogenesis and molecular tactics for the management of mosquitoes and their vectorial capacity. Bacterial pathogenesis and molecular manipulations have a substantial impact on the biology of mosquitoes, and both strategies change the gene expression and regulation of disease vectors. The strategy for genetic modification is also proved to be excellent for the management of mosquitoes, which halt the development of population via incompatibility of different sex. Therefore, the purpose of the present discussion is to illustrate the impact of both approaches against the vectorial capacity of mosquitoes. Moreover, it could be helpful to understand the relationship of insect-pathogen and to manage various insect vectors as well as diseases.
蚊子是全球多种疾病的主要传播媒介，传播病毒（疟疾、基孔肯雅热、脑炎、黄热病以及登革热）以及细菌病（兔热病）。为了控制蚊子种群的爆发，各种管理计划包括应用化学品，随后是生物和遗传控制。在这里，我们旨在关注细菌发病机制和分子策略在蚊子及其媒介能力管理中的作用。细菌发病机制和分子操作对蚊子的生物学有重大影响，这两种策略都改变了疾病媒介的基因表达和调控。遗传修饰策略也被证明是管理蚊子的绝佳策略，因为它通过不同性别的不相容性阻止了种群的发展。因此，本讨论的目的是说明这两种方法对蚊子媒介能力的影响。此外，它还有助于了解昆虫-病原体的关系，并管理各种昆虫媒介以及疾病。
