The Norwegian Centre for Movement Disorders, University of Bergen, Bergen, Norway; Institute of Biological and Medical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway.
The Norwegian Centre for Movement Disorders, University of Bergen, Bergen, Norway; Department of Neurology, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway.
Parkinsonism Relat Disord. 2020 Sep;78:27-30. doi: 10.1016/j.parkreldis.2020.07.007. Epub 2020 Jul 9.
To disentangle the association between impulsive and compulsive behaviors (ICBs), health-related quality of life (HRQOL), satisfaction with life (SwL), and caregiver distress in dyads of people with Parkinson's disease (PwP) and caregivers.
Data used in this study were obtained from the ongoing Norwegian ParkWest study, a population-based longitudinal cohort study of the incidence, neurobiology and prognosis of PD in Western Norway. One hundred and one dyads of PwP free of dementia and their caregivers were included 5 years after PD diagnosis and inclusion in the ParkWest study. Standardized clinical rating scales were used to evaluate ICBs, HRQOL, SwL and caregiver distress.
Of 101 PwP-caregiver dyads, self-reported ICBs were seen in 33% of PwP and only caregiver-reported ICBs in 12% of PwP. PwP-reported ICBs were associated with poorer HRQOL and SwL, whereas ICBs reported by caregivers only were associated with increased caregiver distress, but not poorer HRQOL or SwL in PwP.
ICBs have adverse effects on HRQOL, SwL and caregiver distress. These findings underpin the need for proper identification and management of ICBs in PwP.
为了厘清帕金森病患者及其照料者之间冲动和强迫行为（ICBs）、与健康相关的生活质量（HRQOL）、生活满意度（SwL）和照料者痛苦之间的关联。
本研究使用的数据来自正在进行的挪威 ParkWest 研究，这是一项针对挪威西部帕金森病的发病率、神经生物学和预后的基于人群的纵向队列研究。在帕金森病诊断和纳入 ParkWest 研究 5 年后，纳入了 101 对无痴呆的帕金森病患者及其照料者。使用标准化临床评分量表评估 ICBs、HRQOL、SwL 和照料者痛苦。
在 101 对帕金森病患者-照料者中，33%的帕金森病患者报告存在 ICBs，而只有 12%的帕金森病患者报告存在照料者报告的 ICBs。帕金森病患者报告的 ICBs与较差的 HRQOL 和 SwL 相关，而仅由照料者报告的 ICBs与照料者痛苦增加相关，但与帕金森病患者的 HRQOL 或 SwL 较差无关。
ICBs 对 HRQOL、SwL 和照料者痛苦有不良影响。这些发现强调了在帕金森病患者中正确识别和管理 ICBs 的必要性。
