School of Biosciences and Technology, VIT, Vellore, India.
Nyro Research India, Kochi, Kerala, India.
Chem Biol Drug Des. 2020 Oct;96(4):1069-1083. doi: 10.1111/cbdd.13759. Epub 2020 Aug 24.
Aging is a biological process which accounts for the deterioration of effective physiological functions. The malfunctioning of vital organ systems leads to the onset of neurodegenerative, cardiovascular, and immunomodulatory diseases in the elder population. Age-dependent mitochondrial dysfunctions trigger the production of reactive oxygen species, which serve as a major contributing factor for the onset of age-associated diseases. The increasing burden of age-related pathologies explicates the relevance of identifying novel therapeutic agents with enhanced potency and bioavailability. Key information on the biological mechanisms of significant age-related diseases aids in understanding relevant druggable targets essential for the initiation and progression of the disease. This review provides detailed insights into the druggable targets of key anti-aging properties of therapeutic agents such as anti-oxidant, immunomodulation, cardioprotection, anti-melanogenic, and anti-elastase properties. This information aids in the development of novel therapeutic agents/ supplements with enhanced efficacy.
衰老是一个生物学过程，它导致有效的生理功能恶化。重要器官系统的故障会导致老年人群中神经退行性、心血管和免疫调节疾病的发生。与年龄相关的线粒体功能障碍会触发活性氧的产生，这是导致与年龄相关疾病发生的一个主要因素。与年龄相关的病理的负担增加说明了识别具有增强效力和生物利用度的新型治疗剂的相关性。关于与年龄相关疾病的生物学机制的重要信息有助于理解对于疾病的开始和进展至关重要的相关可用药靶点。本综述深入了解了抗氧化、免疫调节、心脏保护、抗黑色素生成和抗弹性蛋白酶等治疗剂的关键抗衰老特性的可用药靶点。这些信息有助于开发具有增强疗效的新型治疗剂/补充剂。
