Department of Biotechnology, School of Biosciences and Technology, VIT, Vellore, India.
Department of Biotechnology, School of Biosciences and Technology, VIT, Vellore, India; Nyro Research India, Cochin, Kerala, India.
Life Sci. 2021 Apr 1;270:119079. doi: 10.1016/j.lfs.2021.119079. Epub 2021 Jan 15.
Age-associated memory loss is highly prevalent in the elder population. The inception of neurodegenerative diseases acts as a causative factor for the onset of memory loss in aged individuals. The pathophysiological mechanisms of memory loss associated with the onset of neurodegenerative diseases and normal aging processes share certain similarities as well as differences. The normal age-associated memory loss is attributed to the impairment of calcium metabolism, dysregulated cholesterol metabolism, the prevalence of oxidative stress, inappropriate functioning of hormones as well as genetic factors. Vital information regarding the key biological processes and the druggable targets involved in the onset of memory loss in the elder population has been provided in this article. The genomic and proteomic profiles of key druggable targets retrieved from the experimental evidence, co-expression studies and databases are also presented in this article. The genomic and proteomic information of druggable targets will aid in the identification of therapeutic agents which could effectively regulate the key biological processes involved in the age-associated memory loss.
与年龄相关的记忆丧失在老年人群中非常普遍。神经退行性疾病的发生是导致老年人记忆丧失的一个原因。与神经退行性疾病和正常衰老过程相关的记忆丧失的病理生理机制既有相似之处，也有不同之处。正常的与年龄相关的记忆丧失归因于钙代谢受损、胆固醇代谢失调、氧化应激的流行、激素功能不当以及遗传因素。本文提供了有关老年人群记忆丧失发生的关键生物过程和可药物治疗靶点的重要信息。本文还介绍了从实验证据、共表达研究和数据库中检索到的关键可药物治疗靶点的基因组和蛋白质组谱。可药物治疗靶点的基因组和蛋白质组信息将有助于识别有效的治疗剂，这些治疗剂可以有效地调节与年龄相关的记忆丧失相关的关键生物过程。
