Public Health Laboratory of Valencia, 21, Avenida Catalunya, 46020, Valencia, Spain; Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, 21, Avenida Catalunya, 46020, Valencia, Spain; Analytical Chemistry Department, University of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100, Burjassot, Spain.
Public Health Laboratory of Valencia, 21, Avenida Catalunya, 46020, Valencia, Spain.
Chemosphere. 2020 Sep;255:127003. doi: 10.1016/j.chemosphere.2020.127003. Epub 2020 May 10.
In this study, we assessed the presence of 14 phthalate metabolites in the urine of 104 lactating mothers from Valencia (Spain) who took part in the human biomonitoring project BETTERMILK. Nine of the metabolites studied showed detection frequencies >80%, whereas the rest of the metabolites presented low detection frequencies (<5%). The concentrations ranged from <LoQ to 1291 ng/mL with monoethyl phthalate showing the highest concentration, with a geometric mean of 34.90 ng/mL. In general, the phthalate metabolite levels quantified in the present study were lower than the urinary levels found in previous studies that involved lactating mothers. The consumption of packaged juices and the frequency of deodorant usage were predictors of some phthalate metabolite levels in urine. In order to put the biomonitoring data in a risk assessment context, guide values for the different phthalates were used and the respective hazard quotients were calculated, which ranged from 0.0036 (benzylbutyl phthalate) to 0.49 (di-2-ethylhexyl phthalate) at the 95th percentile level. Consequently, no risk was appreciated in the studied population.
在这项研究中，我们评估了来自西班牙巴伦西亚的 104 名哺乳期母亲尿液中 14 种邻苯二甲酸酯代谢物的存在情况，这些母亲参与了 BETTERMILK 人体生物监测项目。在所研究的 9 种代谢物中，检测到的频率>80%，而其余代谢物的检测频率较低(<5%)。浓度范围从<定量下限到 1291ng/mL，其中单乙基邻苯二甲酸酯的浓度最高，几何平均值为 34.90ng/mL。总的来说，本研究中定量的邻苯二甲酸酯代谢物水平低于以前涉及哺乳期母亲的研究中发现的尿液水平。包装果汁的消费和使用除臭剂的频率是尿液中某些邻苯二甲酸酯代谢物水平的预测因子。为了将生物监测数据置于风险评估背景下，使用了不同邻苯二甲酸的指导值，并计算了相应的危害系数，在第 95 个百分位数水平，从 0.0036（苄基丁基邻苯二甲酸酯）到 0.49（邻苯二甲酸二(2-乙基己基)酯）不等。因此，在所研究的人群中没有发现风险。
