Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain.
Public Health Laboratory of Valencia, Av. Cataluña, 21, 46020 Valencia, Spain.
Int J Environ Res Public Health. 2021 Aug 24;18(17):8909. doi: 10.3390/ijerph18178909.
Exposure to emerging contaminants, such as phthalates, bisphenols and parabens in children has been associated with possible neurodevelopment and endocrine alterations. In the present study, the biomonitoring of biomarkers in children (5-12 years old) from the Valencia Region (Spain) have been implemented using urines from the BIOVAL program. More than 75% of the children studied ( = 562) were internally exposed (>LOQ) to bisphenols and parabens, and the whole population assessed ( = 557) were exposed to at least one phthalate. The geometric means (GM) of the concentrations of bisphenol A, methyl paraben and propyl paraben were 0.9, 1.4 and 0.39 ng/mL, respectively. Regarding phthalates, monoethyl phthalate GM was 55.0 ng/mL and diethyl hexyl phthalate (as the sum of five metabolites) GM was 60.6 ng/mL. Despite the studied population being widely exposed, the detection frequencies and concentrations were in general lower than in previous studies involving children in Spain and in other countries in recent years. Furthermore, the risk assessment study concluded that the internal exposure to phthalates, bisphenols and parabens is lower than the guidance values established, and, therefore, a health risk derived from the exposure to these compounds in the studied population is not expected.
儿童接触邻苯二甲酸酯、双酚类和对羟基苯甲酸酯等新兴污染物，可能与神经发育和内分泌紊乱有关。本研究采用生物监测方法，对西班牙巴伦西亚地区（Valencia Region）5-12 岁儿童（共 562 人）的尿液样本进行生物标志物检测，这些样本均来自 BIOVAL 项目。研究发现，超过 75%的儿童（=562）体内存在双酚类和对羟基苯甲酸酯（>LOQ），且所有评估人群（=557）至少接触过一种邻苯二甲酸酯。研究结果显示，双酚 A、甲基对羟基苯甲酸酯和丙基对羟基苯甲酸酯的浓度几何均值（GM）分别为 0.9、1.4 和 0.39ng/mL。在邻苯二甲酸酯方面，邻苯二甲酸单乙酯的 GM 为 55.0ng/mL，邻苯二甲酸二（2-乙基己基）酯（五种代谢物的总和）的 GM 为 60.6ng/mL。尽管研究人群普遍暴露于这些污染物中，但与近年来西班牙和其他国家的类似研究相比，本研究中的检测频率和浓度通常较低。此外，风险评估研究表明，儿童体内接触的邻苯二甲酸酯、双酚类和对羟基苯甲酸酯的水平低于既定的指导值，因此，预计研究人群不会因接触这些化合物而产生健康风险。
