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[Complications and risks associated with an anticoagulation therapy combining low molecular weight heparin and Warfarin after total replacement of large joints--our experience].[全膝关节置换术后低分子肝素与华法林联合抗凝治疗的并发症及风险——我们的经验]
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本文引用的文献

1
Anticoagulation management in individuals with hip fracture.髋部骨折患者的抗凝管理。
J Am Geriatr Soc. 2014 Jan;62(1):159-64. doi: 10.1111/jgs.12591. Epub 2014 Jan 2.
2
Comparison of different warfarin reversal protocols on surgical delay and complication rate in hip fracture patients.不同华法林逆转方案对髋部骨折患者手术延迟和并发症发生率的比较。
J Orthop Surg (Hong Kong). 2013 Aug;21(2):142-5. doi: 10.1177/230949901302100204.
3
Treatment with vitamin K in hip fracture patients receiving warfarin.接受华法林治疗的髋部骨折患者使用维生素K治疗。
Isr Med Assoc J. 2013 Jul;15(7):348-51.
4
Operative treatment of hip fractures in patients on clopidogrel: a case-control study.氯吡格雷治疗患者髋部骨折的手术治疗:一项病例对照研究。
Iowa Orthop J. 2012;32:95-9.
5
Safety of clopidogrel in hip fracture surgery.髋关节骨折手术中氯吡格雷的安全性。
Mayo Clin Proc. 2013 Feb;88(2):149-56. doi: 10.1016/j.mayocp.2012.11.007.
6
Timing matters in hip fracture surgery: patients operated within 48 hours have better outcomes. A meta-analysis and meta-regression of over 190,000 patients.髋部骨折手术的时机很重要:在 48 小时内接受手术的患者有更好的结果。一项对超过 19 万名患者的荟萃分析和荟萃回归研究。
PLoS One. 2012;7(10):e46175. doi: 10.1371/journal.pone.0046175. Epub 2012 Oct 3.
7
The combined effect of ADL impairment and delay in time from fracture to surgery on 12-month mortality: an observational study in orthogeriatric patients.日常生活活动能力受损与骨折至手术时间延迟对 12 个月死亡率的综合影响:矫形老年患者的观察性研究。
J Am Med Dir Assoc. 2012 Sep;13(7):664.e9-664.e14. doi: 10.1016/j.jamda.2012.06.007. Epub 2012 Jul 13.
8
The effects of clopidogrel (Plavix) and other oral anticoagulants on early hip fracture surgery.氯吡格雷(波立维)和其他口服抗凝剂对早期髋部骨折手术的影响。
J Orthop Trauma. 2012 Oct;26(10):568-73. doi: 10.1097/BOT.0b013e318240d70f.
9
Anticoagulation management in hip fracture patients: a clinical conundrum.髋部骨折患者的抗凝管理:一个临床难题。
Injury. 2012 Jul;43(7):1224-5. doi: 10.1016/j.injury.2011.08.010. Epub 2011 Sep 6.
10
Use of warfarin is associated with delay in surgery for hip fracture in older patients.华法林的使用与老年髋部骨折患者手术延迟有关。
Hosp Pract (1995). 2011 Feb;39(1):37-40. doi: 10.3810/hp.2011.02.372.

长期服用华法林的髋部骨折患者的术后并发症:基于手术国际标准化比值的比较

Postoperative Complications of Hip Fractures Patients on Chronic Coumadin: A Comparison Based on Operative International Normalized Ratio.

作者信息

Kain Michael S, Saper David, Lybrand Kyle, Bramlett Kasey-Jean, Tornetta Iii Paul, Althausen Peter, Garfi John S, Willier Iii Donald P, Niu Ruijia, Marcantonio Andrew J

机构信息

Department of Orthopaedic Surgery, Boston Medical Center, 850 Harrison Avenue, Boston, MA 02118, USA.

Orthopaedic and Rehabilitation Centers, 5616 North Western Avenue, Chicago, IL 60659, USA.

出版信息

Geriatrics (Basel). 2020 Jul 15;5(3):43. doi: 10.3390/geriatrics5030043.

DOI:10.3390/geriatrics5030043
PMID:32679667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7555195/
Abstract

In current clinical practice, orthopedic surgeons often delay the surgery intervention on geriatric hip fracture patients to optimize the international normalized ratio (INR), in order to decrease the risk of postoperative hematological complications. However, some evidence suggests that full reversal protocols may not be necessary, especially for patients with prior thromboembolic history. Our study aims to compare the surgical outcomes of patients with normal versus elevated INR values. We conducted a retrospective chart review on 217 patients who underwent surgeries on hip fractures at two academic trauma centers. We found that in our group (n = 124) of patients with an INR value of 1.5-3.0, there was only one reoperation for a hematoma, but there was a trend for more blood transfusions. There was no statistically significant difference in the odds of reoperation or overall complications. Nevertheless, there were significantly more events of postoperative anemia in this high INR patient group.

摘要

在当前的临床实践中,骨科医生常常推迟对老年髋部骨折患者的手术干预,以优化国际标准化比值(INR),从而降低术后血液学并发症的风险。然而,一些证据表明,完全逆转方案可能并非必要,尤其是对于有既往血栓栓塞病史的患者。我们的研究旨在比较INR值正常与升高的患者的手术结果。我们对在两个学术创伤中心接受髋部骨折手术的217例患者进行了回顾性病历审查。我们发现,在我们的INR值为1.5至3.0的患者组(n = 124)中,只有1例因血肿进行了再次手术,但输血次数有增加的趋势。再次手术或总体并发症的几率没有统计学上的显著差异。尽管如此,在这个高INR值患者组中,术后贫血事件明显更多。