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造血SHIP1在人结直肠癌中的异位表达。

Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer.

作者信息

Schaks Matthias, Allgoewer Kristina, Nelson Nina, Ehm Patrick, Heumann Asmus, Ewald Florian, Schumacher Udo, Simon Ronald, Sauter Guido, Jücker Manfred

机构信息

Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.

Department of Pathology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.

出版信息

Biomedicines. 2020 Jul 15;8(7):215. doi: 10.3390/biomedicines8070215.

DOI:10.3390/biomedicines8070215
PMID:32679836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7400281/
Abstract

Colorectal cancer (CRC) is a heterogeneous disease that results from the accumulation of mutations in colonic mucosa cells. A subclass of CRC is characterized by microsatellite instability, which is thought to occur mainly through inactivation of the DNA mismatch repair genes and . The inositol 5-phosphatase SHIP1 is expressed predominantly in hematopoietic cells. In this study, the expression of SHIP1 in carcinomas and its putative correlation with clinicopathologic parameters, expression of DNA repair genes and microsatellite instability was investigated. By analyzing a multi-tumor tissue microarray, expression of SHIP1 was detected in 48 out of 72 cancer entities analyzed. The expression of SHIP1 protein of 145 kDa was confirmed by Western blot analysis in 7 out of 14 carcinoma cell lines. Analysis of a large colorectal cancer tissue microarray with 1009 specimens revealed SHIP1 expression in 62% of the samples analyzed. SHIP1 expression was inversely correlated with lymph node metastasis, vascular invasion and tumor grade, and it was positively associated with left-sided tumor localization. Interestingly, a strong relationship between the expression of SHIP1 and nuclear and membranous beta-catenin and the DNA repair genes and was observed.

摘要

结直肠癌（CRC）是一种异质性疾病，由结肠黏膜细胞中的突变积累所致。CRC的一个亚类以微卫星不稳定性为特征，这种不稳定性被认为主要通过DNA错配修复基因和的失活而发生。肌醇5-磷酸酶SHIP1主要在造血细胞中表达。在本研究中，对SHIP1在癌组织中的表达及其与临床病理参数、DNA修复基因表达和微卫星不稳定性的假定相关性进行了研究。通过分析多肿瘤组织芯片，在所分析的72个癌症实体中的48个中检测到了SHIP1的表达。通过蛋白质印迹分析在14个癌细胞系中的7个中证实了145 kDa的SHIP1蛋白的表达。对含有1009个标本的大型结直肠癌组织芯片进行分析，结果显示在所分析的样本中有62%表达SHIP1。SHIP1的表达与淋巴结转移、血管侵犯和肿瘤分级呈负相关，与肿瘤位于左侧呈正相关。有趣的是，观察到SHIP1的表达与细胞核和细胞膜β-连环蛋白以及DNA修复基因和之间存在密切关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/69df0d377c01/biomedicines-08-00215-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/31004f3c5980/biomedicines-08-00215-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/4be1bc8949df/biomedicines-08-00215-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/d91dec170c08/biomedicines-08-00215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/69df0d377c01/biomedicines-08-00215-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/31004f3c5980/biomedicines-08-00215-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/4be1bc8949df/biomedicines-08-00215-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/d91dec170c08/biomedicines-08-00215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b3/7400281/69df0d377c01/biomedicines-08-00215-g004.jpg

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2
Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.突触结合蛋白2是一种可成药的转移介质，该基因在乳腺癌中过表达并扩增。
Sci Signal. 2015 Jan 20;8(360):ra7. doi: 10.1126/scisignal.2005537.
3
Sporadic microsatellite instability-high colon cancers rarely display immunohistochemical evidence of Wnt signaling activation.
SHIP1结构域对肌醇5-磷酸酶活性贡献的功能表征
Biomolecules. 2025 Jan 10;15(1):105. doi: 10.3390/biom15010105.
4
The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases.Src 同源性 2 结构域包含肌醇 5-磷酸酶 SHIP1 和 SHIP2 在人类疾病发病机制中的功能作用。
Int J Mol Sci. 2024 May 11;25(10):5254. doi: 10.3390/ijms25105254.
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Dis Markers. 2014;2014:218968. doi: 10.1155/2014/218968. Epub 2014 Nov 24.
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