Sakai Naomi, Futaki Shiroh, Matile Stefan
Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.
Institute for Chemical Research, Kyoto University, Kyoto, Japan and PRESTO, JST, Kyoto, Japan.
Soft Matter. 2006 Jul 20;2(8):636-641. doi: 10.1039/b606955j.
Rapid progress in the understanding of counteranions as either activators or inactivators of guanidinium-rich macromolecules is summarized. From phase transfer of polyarginine into chloroform to the cytosolic delivery of green-fluorescent proteins or apoptosis-inducing peptides with cell-penetrating peptides, counteranions emerge consistently as the origin of function. A unified view of this "demystified arginine magic" is proposed, focusing on the manipulation of the underlying anion hopping of and on these sticky molecular chameleons according to the principle of Le Chatelier.
本文总结了在理解抗衡阴离子作为富含胍基的大分子的激活剂或失活剂方面取得的快速进展。从聚精氨酸向氯仿的相转移，到利用细胞穿透肽进行绿色荧光蛋白或凋亡诱导肽的胞质递送，抗衡阴离子始终作为功能的起源出现。本文提出了对这种“揭开神秘面纱的精氨酸魔力”的统一观点，重点是根据勒夏特列原理对这些粘性分子变色龙的潜在阴离子跳跃进行调控。
