Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, 464-8650, Japan.
Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558, Japan.
Environ Health Prev Med. 2020 Jul 17;25(1):30. doi: 10.1186/s12199-020-00868-3.
Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enhance methylmercury toxicity. In addition, methylmercury exposure induces several immune-related chemokines, specifically in the brain, and may cause neurotoxicity. This summary highlights several molecular mechanisms of methylmercury-induced neurotoxicity.
甲基汞是一种环境污染物，可导致神经毒性。最近的研究报告称，泛素-蛋白酶体系统通过降解合成丙酮酸的蛋白质来参与抵御甲基汞毒性。丙酮酸在线粒体中的积累会增强甲基汞的毒性。此外，甲基汞暴露会诱导几种免疫相关趋化因子，特别是在大脑中，可能导致神经毒性。本综述强调了甲基汞诱导的神经毒性的几种分子机制。
