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一项聚焦于促进身体活动和健康生活方式的瑞典初级卫生保健预防计划降低了心血管事件和死亡率:5761 名研究参与者和对照组的 22 年随访结果。

A Swedish primary healthcare prevention programme focusing on promotion of physical activity and a healthy lifestyle reduced cardiovascular events and mortality: 22-year follow-up of 5761 study participants and a reference group.

机构信息

Unit of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

出版信息

Br J Sports Med. 2020 Nov;54(21):1294-1299. doi: 10.1136/bjsports-2019-101749. Epub 2020 Jul 17.

Abstract

OBJECTIVE

To evaluate long-term risk of first cardiovascular (CV) events, CV deaths and all-cause deaths in community-dwelling participants of a cardiovascular disease (CVD) prevention programme delivered in a primary care setting.

METHODS

Individuals who visited a primary healthcare service in Sollentuna (Sweden) and agreed to participate in the programme between 1988 and 1993 were followed. They had at least one CV risk factor but no prior myocardial infarction and received support to increase physical activity using the programme Physical Activity on Prescription and to adopt health-promoting behaviours including cooking classes, weight reduction, smoking cessation and stress management. Participants (n=5761) were compared with a randomly selected, propensity score-matched reference group from the general population in Stockholm County (n=34 556). All individuals were followed in Swedish registers until December 2011.

RESULTS

In the intervention group and the reference group there were 698 (12.1%) and 4647 (13.4%) first CV events, 308 (5.3%) and 2261 (6.5%) CV deaths, and 919 (16.5%) and 6405 (18.5%) all-cause deaths, respectively, during a mean follow-up of 22 years. The HR (95% CI) in the intervention group compared with the reference group was 0.88 (0.81 to 0.95) for first CV events, 0.79 (0.70 to 0.89) for CV deaths and 0.83 (0.78 to 0.89) for all-cause deaths.

CONCLUSIONS

Participation in a CVD prevention programme in primary healthcare focusing on promotion of physical activity and healthy lifestyle was associated with lower risk of CV events (12%), CV deaths (21%) and all-cause deaths (17%) after two decades. Promoting physical activity and healthy living in the primary healthcare setting may prevent CVD.

摘要

目的

评估在初级保健环境中实施的心血管疾病(CVD)预防计划中社区居民的首次心血管(CV)事件、CV 死亡和全因死亡的长期风险。

方法

随访于 1988 年至 1993 年期间访问瑞典索伦蒂纳初级医疗保健服务并同意参加该计划的个体。他们至少有一个 CV 风险因素,但没有先前的心肌梗死,并通过“处方运动”计划接受支持以增加体力活动,并采用健康促进行为,包括烹饪课程、减肥、戒烟和压力管理。将参与者(n=5761)与斯德哥尔摩县随机选择的、倾向评分匹配的一般人群参考组(n=34556)进行比较。所有个体均在瑞典登记册中随访至 2011 年 12 月。

结果

在干预组和参考组中,分别有 698(12.1%)和 4647(13.4%)例首次 CV 事件、308(5.3%)和 2261(6.5%)例 CV 死亡以及 919(16.5%)和 6405(18.5%)例全因死亡,平均随访时间为 22 年。与参考组相比,干预组的 HR(95%CI)分别为首次 CV 事件 0.88(0.81 至 0.95)、CV 死亡 0.79(0.70 至 0.89)和全因死亡 0.83(0.78 至 0.89)。

结论

在初级保健中参与以促进体力活动和健康生活方式为重点的 CVD 预防计划与二十年后 CV 事件(12%)、CV 死亡(21%)和全因死亡(17%)风险降低相关。在初级保健环境中促进体力活动和健康生活方式可能预防 CVD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2173/7588408/4f4faa8f52f7/bjsports-2019-101749f01.jpg

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