Small molecule AX-024 targets T cell receptor signaling by disrupting CD3ε-Nck interaction.
作者信息
Alarcon Balbino, Borroto Aldo
机构信息
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Madrid, Spain
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
出版信息
J Biol Chem. 2020 Jul 17;295(29):10076. doi: 10.1074/jbc.L120.014338.
Abstract
摘要
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Small molecule AX-024 targets T cell receptor signaling by disrupting CD3ε-Nck interaction.小分子AX-024通过破坏CD3ε-Nck相互作用来靶向T细胞受体信号传导。
J Biol Chem. 2020 Jul 17;295(29):10076. doi: 10.1074/jbc.L120.014338.
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Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.小分子 AX-024 通过 Nck1-SH3.1 结构域的结构域交换来独立于 CD3ϵ/Nck1 相互作用来减少 T 细胞增殖。
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Reply to Alarcon and Borroto: Small molecule AX-024 reduces T cell proliferation independently of CD3ε-Nck1 interaction at SH3.1.对阿拉尔孔和博罗托的回复：小分子AX-024独立于SH3.1处的CD3ε-Nck1相互作用降低T细胞增殖。
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Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.CD3ε招募Nck揭示了一种对T细胞受体信号传导和突触形成至关重要的配体诱导构象变化。
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Reply to Alarcon and Borroto: Small molecule AX-024 reduces T cell proliferation independently of CD3ε-Nck1 interaction at SH3.1.对阿拉尔孔和博罗托的回复：小分子AX-024独立于SH3.1处的CD3ε-Nck1相互作用降低T细胞增殖。
J Biol Chem. 2020 Jul 17;295(29):10077. doi: 10.1074/jbc.RL120.014441.
本文引用的文献
1
Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.小分子 AX-024 通过 Nck1-SH3.1 结构域的结构域交换来独立于 CD3ϵ/Nck1 相互作用来减少 T 细胞增殖。
J Biol Chem. 2020 Jun 5;295(23):7849-7864. doi: 10.1074/jbc.RA120.012788. Epub 2020 Apr 21.
2
Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor.抗CD3 Fab片段增强人γδ T细胞的肿瘤杀伤作用，且不依赖Nck募集至γδ T细胞抗原受体。
Front Immunol. 2018 Jul 9;9:1579. doi: 10.3389/fimmu.2018.01579. eCollection 2018.
3
First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.治疗自身免疫性疾病的 T 细胞受体的首创抑制剂。
Sci Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.
4
ZAP-70: an essential kinase in T-cell signaling.ZAP-70：T 细胞信号转导中的必需激酶。
Cold Spring Harb Perspect Biol. 2010 May;2(5):a002279. doi: 10.1101/cshperspect.a002279.
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