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[格雷夫斯眼眶病的眼眶减压——经验与结果]

[Orbital decompression in Graves' orbitopathy-Experiences and results].

作者信息

Küchlin Sebastian, Gruber Markus, Reich Michael, Joachimsen Lutz, Metzger Marc, Beck Jürgen, Grauvogel Jürgen, Lagrèze Wolf A

机构信息

Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.

Interdisziplinäres Orbitazentrum, Universitätsklinikum Freiburg, Freiburg, Deutschland.

出版信息

Ophthalmologe. 2021 Apr;118(4):345-355. doi: 10.1007/s00347-020-01181-8.

Abstract

BACKGROUND

Graves' orbitopathy is the most frequent extrathyroidal manifestation of Graves' disease, affecting approximately 25-50% of patients. It leads to inflammation and swelling of orbital soft tissues. The treatment is mostly conservative. Surgical orbital decompression is indicated in severe cases with disfiguring exophthalmos or an acute steroid-refractive threat to vision, facilitating visual and cosmetic recovery. An important aspect in the quality of care is the avoidance of postoperative diplopia.

OBJECTIVE

To report experiences and results from 100 cases of orbital decompression surgery performed on 62 patients at a multidisciplinary orbit center. Patients with signs of apical crowding were treated by pterional decompression. Patients without signs of apical crowding were treated either by deep lateral wall resection or pterional decompression.

METHODS

A retrospective data analysis was carried out.

RESULTS

The mean reduction in exophthalmos was 2.9 mm. Visual acuity improved by a mean of 2.2 lines in eyes with sight-threatening disease. In moderate to severe disease, visual acuity remained stable. The complication rate was 4%. New postoperative diplopia occurred after two interventions and one patient experienced a deterioration in visual acuity from 0.8 to 0.1. In nine cases, surgery led to a complete regression of previously reported double vision.

CONCLUSION

Visual acuity gain, reduction of exophthalmos and complications in this collective are comparable to previously published results. The results of this study confirm the role of orbital decompression in the treatment of sight-threatening and severely disfiguring endocrine orbitopathy.

摘要

背景

格雷夫斯眼眶病是格雷夫斯病最常见的甲状腺外表现,约25%-50%的患者会受其影响。它会导致眼眶软组织炎症和肿胀。治疗大多采用保守疗法。严重病例出现毁容性眼球突出或急性类固醇抵抗性视力威胁时,需进行眼眶减压手术,以促进视力恢复和改善外观。护理质量的一个重要方面是避免术后复视。

目的

报告在一个多学科眼眶中心对62例患者进行的100例眼眶减压手术的经验和结果。有眶尖拥挤迹象的患者采用翼点减压术治疗。无眶尖拥挤迹象的患者则采用外侧壁深层切除术或翼点减压术治疗。

方法

进行回顾性数据分析。

结果

眼球突出平均减少2.9毫米。有视力威胁疾病的眼睛视力平均提高2.2行。在中度至重度疾病中,视力保持稳定。并发症发生率为4%。两次干预后出现新的术后复视,一名患者视力从0.8降至0.1。9例患者手术后先前报告的复视完全消失。

结论

该组患者的视力提高、眼球突出减少及并发症情况与先前发表的结果相当。本研究结果证实了眼眶减压在治疗有视力威胁和严重毁容的内分泌性眼眶病中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bea3/8043865/0de9b0988574/347_2020_1181_Fig1_HTML.jpg

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