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Graves 眼病患者行眼眶减压术后的生活质量:平衡法与中外侧联合入路法的比较。

Quality of life in patients with Graves' orbitopathy submitted to orbital decompression: comparison between balanced and inferomedial techniques.

机构信息

Laboratory of Investigation in Ophthalmology (LIM 33), Division of Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

出版信息

Arq Bras Oftalmol. 2024 Aug 5;87(5):e20230296. doi: 10.5935/0004-2749.2023-0296. eCollection 2024.

DOI:10.5935/0004-2749.2023-0296
PMID:39109703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11627165/
Abstract

PURPOSE

To compare inferomedial wall orbital decompression to balanced medial plus lateral wall orbital decompression in patients with Graves' orbitopathy in the inactive phase with regard to exophthalmos reduction and the effects on quality of life.

METHODS

Forty-two patients with inactive Graves' orbitopathy were randomly divided into two groups and submitted to one of two orbital decompression techniques: inferomedial wall orbital decompression or medial plus lateral wall orbital decompression. Preoperative and postoperative assessments included Hertel's exophthalmometry and a validated Graves' orbitopathy quality of life questionnaire. The results of the two groups were compared.

RESULTS

Compared to preoperative measurement, exophthalmos reduction was statistically significant in both groups (p<0.001) but more so in patients undergoing medial plus lateral wall orbital decompression (p=0.010). Neither orbital decompression techniques increased the visual functioning subscale score on the Graves' orbitopathy quality of life questionnaire (inferomedial wall orbital decompression p=0.362 and medial plus lateral wall orbital decompression p=0.727), but a statistically significant difference was observed in the score of the appearance subscale in patients submitted to medial plus lateral wall orbital decompression (p=0.006).

CONCLUSIONS

Inferomedial wall orbital decompression is a good alternative for patients who do not require large exophthalmos reduction. However, medial plus lateral wall orbital decompression offers greater exophthalmos reduction and greater improvement in appearance (higher Graves' orbitopathy quality of life questionnaire scores), making it a suitable option for esthetic-functional rehabilitation.

摘要

目的

比较在静止期 Graves 眼病患者中,内侧壁联合下壁眶减压术与单纯内侧壁眶减压术治疗突眼的效果。

方法

42 例静止期 Graves 眼病患者随机分为两组,分别行内侧壁联合下壁眶减压术或单纯内侧壁眶减压术。术前和术后评估包括 Hertel 突眼计和经过验证的 Graves 眼病生活质量问卷。比较两组的结果。

结果

与术前测量值相比,两组突眼度均有统计学意义(p<0.001),但内侧壁联合下壁眶减压组更为显著(p=0.010)。两种眶减压技术均未增加 Graves 眼病生活质量问卷中视觉功能子量表的评分(内侧壁联合下壁眶减压组 p=0.362,内侧壁眶减压组 p=0.727),但内侧壁联合下壁眶减压组在外观子量表的评分上存在统计学差异(p=0.006)。

结论

对于不需要明显突眼度降低的患者,内侧壁眶减压术是一种较好的选择。然而,内侧壁联合下壁眶减压术可提供更大的突眼度降低和更好的外观改善(更高的 Graves 眼病生活质量问卷评分),是美学和功能康复的理想选择。

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本文引用的文献

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Clinics (Sao Paulo). 2021 Apr 9;76:e2592. doi: 10.6061/clinics/2021/e2592. eCollection 2021.
2
Evaluation of Quality of Life in the Brazilian Graves' Disease Population: Focus on Mild and Moderate Graves' Orbitopathy Patients.巴西格雷夫斯病患者生活质量评估:聚焦轻度和中度格雷夫斯眼眶病患者。
Front Endocrinol (Lausanne). 2019 Apr 4;10:192. doi: 10.3389/fendo.2019.00192. eCollection 2019.
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Quality of life and neuropsychiatric disorders in patients with Graves' Orbitopathy: Current concepts.Graves 眼病患者的生活质量和神经精神障碍:当前概念。
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Expression of thyroid-stimulating hormone receptors and thyroglobulin in limbic regions in the adult human brain.促甲状腺激素受体和甲状腺球蛋白在成人大脑边缘区域的表达。
Metab Brain Dis. 2018 Apr;33(2):481-489. doi: 10.1007/s11011-017-0076-3. Epub 2017 Aug 3.
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Customized Minimally Invasive Orbital Decompression Surgery Improves Lower Eyelid Retraction and Contour in Thyroid Eye Disease.定制化微创眼眶减压手术改善甲状腺眼病患者的下睑退缩及外形
Ophthalmic Plast Reconstr Surg. 2017 Nov/Dec;33(6):446-451. doi: 10.1097/IOP.0000000000000825.
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Orbit. 2016 Jun;35(3):121-5. doi: 10.1080/01676830.2016.1176049. Epub 2016 May 9.
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