Park S H, Kim Y I, Kim Y K
Department of Pathology, College of Medicine, Seoul National University, Korea.
J Korean Med Sci. 1987 Sep;2(3):183-7. doi: 10.3346/jkms.1987.2.3.183.
A case of malacoplakia of the prostatic gland associated with prostatic nodular hyperplasia from a 69 years old man was presented, and its light and electron microscopic and immunohistochemical features were discussed along with its pathogenesis. This lesion was incidentally found in a transurethral prostatectomy specimen, and consisted of large number of epithelioid cells in which were typical cytoplasmic inclusions known as Michaelis-Gutmann bodies. Ultrastructurally, these inclusions showed a dense, central calcified bodies of various developmental stages. Immunohistochemical study using antilysosomal antibody revealed no lysosomal activity. Based on these findings, we could suspect that main problem for this development of malacoplakia is altered intracellular digestion process of foreign biologic materials.
报告了一例69岁男性前列腺软斑病合并前列腺结节状增生的病例，并结合其发病机制讨论了其光镜、电镜及免疫组化特征。该病变在经尿道前列腺切除术标本中偶然发现，由大量上皮样细胞组成，其中含有典型的胞质内包涵体，即米氏小体。超微结构上，这些包涵体显示出不同发育阶段的致密中央钙化体。使用抗溶酶体抗体的免疫组化研究未显示溶酶体活性。基于这些发现，我们推测软斑病发生的主要问题是外来生物材料的细胞内消化过程发生改变。
