Department of Anesthesiology, Kyoto Chubu Medical Center, Yagi, Ueno 25, Nantan City, Kyoto, Japan; Medical Education and Research Center, Meiji University of Integrative Medicine, Kyoto, Japan.
Department of Anesthesiology, Kyoto Chubu Medical Center, Yagi, Ueno 25, Nantan City, Kyoto, Japan.
Clin Neurophysiol. 2020 Sep;131(9):2150-2157. doi: 10.1016/j.clinph.2020.05.027. Epub 2020 Jun 23.
Although the characteristics of electroencephalograms (EEGs) have been reported to change with age, anaesthesia-dependent oscillatory features and reactivity of the super-elderly EEG to anaesthesia have not been examined in detail.
Participants comprised 20 super-elderly patients (age; mean ± standard deviation, 87.1 ± 3.8 years) and 20 young adult patients (35.5 ± 8.5 years). At three levels of sevoflurane anaesthesia (minimum alveolar concentration [MAC] of 0.3, 0.7, and 1.4), oscillatory features of the frontal EEG were examined by analysing quadratic phase coupling (bicoherence) and power spectrum in α and δ-θ areas and compared in an anaesthesia-dependent manner, using the Friedman test.
Among super-elderly individuals, bicoherences in the δ-θ area showed anaesthesia-dependent increases (median [interquartile range], 12.9% [5.2%], 19.2% [9.1%], 23.3% [8.7%]; 0.3, 0.7, 1.4 MAC sevoflurane, p = 0.000), whereas bicoherence in the α area did not change at these different anaesthesia levels (11.2% [3.9%], 12.5% [4.4%], 14.1% [5.7%], respectively; p = 0.142), counter to the results found in young adult patients, where both δ-θ and α bicoherences changed with anaesthesia.
In the super-elderly, δ-θ bicoherence of EEG shows anaesthesia- dependent changes, whereas α activity remains small irrespective of anaesthesia level.
Quantification of δ-θ bicoherence is a candidate for anaesthesia monitoring in the super-elderly.
尽管脑电图（EEG）的特征已被报道随年龄而变化，但尚未详细检查超老年患者的麻醉相关振荡特征和对麻醉的反应性。
参与者包括 20 名超老年患者（年龄；均值±标准差，87.1±3.8 岁）和 20 名年轻成年患者（35.5±8.5 岁）。在三个七氟醚麻醉水平（最低肺泡浓度[MAC]为 0.3、0.7 和 1.4）下，通过分析前脑 EEG 的二次相位耦合（双相干）和 α 与 δ-θ 频段的功率谱，以弗里德曼检验比较麻醉依赖的振荡特征。
在超老年个体中，δ-θ 频段的双相干显示出麻醉依赖性增加（中位数[四分位数范围]，12.9%[5.2%]、19.2%[9.1%]、23.3%[8.7%]；0.3、0.7、1.4 MAC 七氟醚，p=0.000），而 α 频段的双相干在不同麻醉水平下没有变化（11.2%[3.9%]、12.5%[4.4%]、14.1%[5.7%]，p=0.142），与年轻成年患者的结果相反，其中 δ-θ 和 α 双相干均随麻醉而变化。
在超老年患者中，EEG 的 δ-θ 双相干显示出麻醉依赖性变化，而 α 活动则保持不变，无论麻醉水平如何。
δ-θ 双相干的量化可能是超老年患者麻醉监测的候选方法。
