Department of Gastroenterology, University Hospital "Tsaritsa Yoanna-ISUL", Medical University Sofia, Sofia, Bulgaria.
Curr Drug Metab. 2020;21(11):838-843. doi: 10.2174/1389200221666200719002652.
Oral administration of medications and current oral modified-release systems are the most preferred drug delivery routes, but they provide efficacy up to 12-24 hours per administration and are not useful when the patient has short transit time. The once-daily administered formulations are the endpoint of many types of drug development, and some innovations in capsule endoscopy (CE) can solve this problem.
This review aims to reveal recent advances in drug delivery systems (DDS) for CE as an essential field of research for more precise drug targeting at the gastrointestinal (GI) tract.
We performed a narrative overview of the MEDLINE database from 1991-2020 using the keywords of DDS and CE with synthesizing the findings, hand searches, and authoritative articles.
There are microelectromechanical systems and non-mechanical patent technologies for DDS for CE, and the implementation of wireless-capsule medical devices into the human body will provide new diagnostic and therapeutic options. Integrating biomedical CE with DDS and the cloud technology will bring remote real-time feedbackbased automated treatment or responsive medication.
Swallowable drug delivery systems for capsule endoscopy brings an entirely new approach for diagnostic and therapeutic methods in digestive diseases.
药物的口服给药和当前的口服改良释放系统是最受青睐的药物输送途径，但它们的疗效每 12-24 小时给药一次，对于那些通过时间较短的患者并不适用。每日一次给药的制剂是许多药物开发类型的终点，而胶囊内镜（CE）的一些创新可以解决这个问题。
本综述旨在揭示 CE 中药物输送系统（DDS）的最新进展，作为胃肠道（GI）更精确药物靶向的重要研究领域。
我们使用 DDS 和 CE 的关键词，对 1991 年至 2020 年的 MEDLINE 数据库进行了叙述性综述，综合了研究结果、手工搜索和权威文章。
CE 的 DDS 有微机电系统和非机械专利技术，无线胶囊医疗设备的应用将为人体提供新的诊断和治疗选择。将生物医学 CE 与 DDS 和云技术相结合，将带来远程实时反馈的自动化治疗或响应式药物治疗。
胶囊内镜的口服给药系统为消化道疾病的诊断和治疗方法带来了全新的途径。
Zotero 插件