Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Immunology and Allergy, Academic Center for Education, Culture, and Research, Tehran, Iran; Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.
Arch Med Res. 2020 Oct;51(7):608-612. doi: 10.1016/j.arcmed.2020.06.012. Epub 2020 Jun 19.
Corona Virus Disease 2019 (COVID-19) pandemic is rapidly spreading all over the world. Excessive immune responses trigger life-threatening cytokine release syndrome (CRS) which can result in overproduction of pro-inflammatory cytokines including tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and IL-1β with different pro-inflammatory roles. Anecdotal evidence suggests that the modulation of systemic immune responses may have a potential role in the treatment of patients with COVID-19. Given the importance of the issue and the lack of therapeutic treatment or vaccine; anti-cytokine therapy such as IL-6, TNFα and IL-1 antagonists have been suggested for the alleviation of hyper-inflammation status in these patients. In this mini-review, we addressed the inflammatory pathways of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its relationship with the host cytokine storm. Furthermore, the proposed therapeutic options to reverse hyper-inflammation in infected patients were mentioned.
2019 年冠状病毒病（COVID-19）大流行正在迅速在全球蔓延。过度的免疫反应引发危及生命的细胞因子释放综合征（CRS），这可能导致包括肿瘤坏死因子 alpha（TNFα）、白细胞介素-6（IL-6）和 IL-1β在内的促炎细胞因子过度产生，具有不同的促炎作用。一些传闻证据表明，调节全身免疫反应可能在治疗 COVID-19 患者方面具有潜在作用。鉴于这一问题的重要性以及缺乏治疗方法或疫苗；有人建议使用抗细胞因子疗法，如 IL-6、TNFα 和 IL-1 拮抗剂，以减轻这些患者的过度炎症状态。在这篇迷你综述中，我们讨论了严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的炎症途径及其与宿主细胞因子风暴的关系。此外，还提到了逆转感染患者过度炎症的拟议治疗选择。
