Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran.
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Sci Rep. 2024 Aug 16;14(1):18968. doi: 10.1038/s41598-024-67522-8.
COVID-19 is a highly contagious virus that uses Angiotensin-converting enzyme 2 (ACE2) as a receptor to enter human cells. The virus leads to an increase in inflammatory cytokines (i.e. IL-6) and an impaired coagulation system, which can cause serious complications during and after the disease. Physical exercise has been shown to improve COVID-19 complications through various mechanisms, such as modulation of the immune and coagulation systems. Therefore, this study investigated the effects of 8 weeks of training on inflammatory, coagulation, and physical factors in patients with COVID-19 during the recovery phase. Twenty-seven male and female volunteers (age 20-45 years) who recently recovered from COVID-19 were assigned to the control (n = 13) or the training group (n = 14). Blood samples, aerobic capacity and muscle endurance were collected 24 h before the start of the interventions and 24 h after the final training session in week 4 and 48 h after the final training session in week 8. IL-6, ACE2, fibrinogen, and D-dimer were measured using ELISA. The training group showed a significant increase in muscle endurance (p = 0.004) and aerobic capacity (p = 0.009) compared to the control group. Serum levels of IL-6 and fibrinogen decreased in the training group but this decrease was not statistically significant (p > 0.05). Despite a slight increase in the quality of life and sleep in the training group, no statistically significant difference was observed between the training and the control group. It appears that physical training has beneficial effects on the coagulation system, inflammatory factors, and sleep quality and can facilitate the recovery of COVID-19 patients.
COVID-19 是一种高度传染性的病毒，它使用血管紧张素转换酶 2（ACE2）作为受体进入人体细胞。该病毒导致炎症细胞因子（即 IL-6）增加和凝血系统受损，这可能导致疾病期间和之后出现严重并发症。运动已被证明可以通过调节免疫系统和凝血系统等多种机制改善 COVID-19 并发症。因此，本研究调查了 8 周的训练对恢复期 COVID-19 患者的炎症、凝血和身体因素的影响。最近从 COVID-19 中康复的 27 名男性和女性志愿者（年龄 20-45 岁）被分配到对照组（n = 13）或训练组（n = 14）。在干预开始前 24 小时和第 4 周的最后一次训练后 24 小时以及第 8 周的最后一次训练后 48 小时采集血液样本、有氧能力和肌肉耐力。使用 ELISA 测量 IL-6、ACE2、纤维蛋白原和 D-二聚体。与对照组相比，训练组的肌肉耐力（p = 0.004）和有氧能力（p = 0.009）显著增加。训练组的血清 IL-6 和纤维蛋白原水平下降，但无统计学意义（p > 0.05）。尽管训练组的生活质量和睡眠略有改善，但训练组和对照组之间没有观察到统计学差异。看来，身体训练对凝血系统、炎症因子和睡眠质量有有益的影响，并可以促进 COVID-19 患者的康复。
