Fukushima Shoji, Cohen Samuel M, Eisenbrand Gerhard, Gooderham Nigel J, Guengerich F Peter, Hecht Stephen S, Rietjens Ivonne M C M, Rosol Thomas J, Davidsen Jeanne M, Harman Christie L, Lu Vivian, Taylor Sean V
Japan Bioassay Research Center ,2445 Hirasawa, Hadano, Kanagawa 257-0015, Japan.
Havlik-Wall Professor of Oncology, Dept. of Pathology and Microbiology, University of Nebraska Medical Center., 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA.
Food Chem Toxicol. 2020 Nov;145:111584. doi: 10.1016/j.fct.2020.111584. Epub 2020 Jul 16.
In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. This publication, fifth in the series, evaluates the safety of NFCs containing linalool and/or other characteristic mono- and sesquiterpenoid tertiary alcohols and esters using the safety evaluation procedure published by the FEMA Expert Panel in 2005 and updated in 2018. The procedure relies on a complete chemical characterization of the NFC intended for commerce and organization of the chemical constituents of each NFC into well-defined congeneric groups. The safety of each NFC is evaluated using the well-established and conservative threshold of toxicological concern (TTC) concept in addition to data on absorption, metabolism and toxicology of both the constituent congeneric groups and the NFCs. Sixteen NFCs, derived from the Lavandula, Aniba, Elettaria, Daucus, Salvia, Coriandrum, Ribes, Guaiacum/Bulnesia, Citrus, Pogostemon, Melaleuca and Michelia genera, were affirmed as generally recognized as safe (GRAS) under their conditions of intended use as flavor ingredients based on an evaluation of each NFC and the constituents and congeneric groups therein.
2015年，香料与提取物制造商协会（FEMA）专家小组启动了一项计划，对250多种用作香料成分的天然香料复合物（NFC）的安全性进行重新评估。本出版物是该系列的第五部，采用FEMA专家小组于2005年发布并于2018年更新的安全评估程序，评估了含有芳樟醇和/或其他特征性单萜和倍半萜叔醇及酯类的NFC的安全性。该程序依赖于对拟用于商业的NFC进行完整的化学表征，并将每个NFC的化学成分组织成明确的同系物组。除了关于组成同系物组和NFC的吸收、代谢及毒理学数据外，还使用成熟且保守的毒理学关注阈值（TTC）概念对每个NFC的安全性进行评估。基于对16种来自薰衣草属、木姜子属、小豆蔻属、胡萝卜属、鼠尾草属、芫荽属、茶藨子属、愈创木属/布氏豆属、柑橘属、刺蕊草属、白千层属和含笑属的NFC及其成分和同系物组的评估，这些NFC在用作香料成分的预期使用条件下被确认为一般认为安全（GRAS）。
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