Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.
Centre for Public Health and Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland, UK.
Cancer Epidemiol. 2020 Oct;68:101780. doi: 10.1016/j.canep.2020.101780. Epub 2020 Jul 16.
This study aimed to investigate the association between physical activity and site-specific cancer incidence.
UK Biobank is a prospective population-based cohort study. 364,899 adults (51.6 % females, mean age 56.0 years) were included. The exposure variable was physical activity level derived from the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Participants were categorised at 'high' (≥1,500 MET-minutes/week), 'moderate' (≥600 MET-minutes/week) or 'low' levels of activity following standardised IPAQ-SF scoring guidance. Primary outcome measures included incident cancers at 20 sites. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) showing relationships between physical activity and cancer.
21,816 incident cancers were identified. Significant associations were identified between high physical activity levels and lower risk of lung (HR 0.81, 95 % CI: 0.70, 0.94), breast (female only) (HR 0.85, 95 % CI: 0.77, 0.94), hepatobiliary tract (HR 0.72, 95 % CI: 0.53, 0.97), and colon (HR 0.86, 95 % CI: 0.74, 0.99) cancers compared to low physical activity levels. Moderate levels of physical activity were associated with significantly lower risk of oropharyngeal (HR 0.71, 95 % CI: 0.55, 0.93), and lung cancer (HR 0.86, 95 % CI: 0.74, 0.99) compared to low physical activity levels. Sensitivity analyses showed associations of higher physical activity with lower oesophageal and higher prostate cancer incidence.
Regular physical activity is significantly associated with reduced risk for lung, breast, hepatobiliary tract, colon and oropharyngeal cancers. Our findings highlight the importance of physical activity promotion, particularly high levels of physical activity, in cancer prevention.
本研究旨在探讨身体活动与特定部位癌症发病风险的关联。
英国生物库（UK Biobank）是一项前瞻性的基于人群的队列研究。共纳入 364899 名成年人（51.6%为女性，平均年龄 56.0 岁）。身体活动水平的暴露变量来源于国际体力活动问卷-短表（IPAQ-SF）。根据 IPAQ-SF 的标准化评分指南，参与者被分为“高”（≥1500MET-分钟/周）、“中”（≥600MET-分钟/周）或“低”活动水平组。主要结局指标包括 20 个部位的癌症发病情况。使用 Cox 比例风险模型来估计风险比（HR）和 95%置信区间（CI），以显示身体活动与癌症之间的关系。
共确定了 21816 例癌症发病事件。高身体活动水平与较低的肺癌（HR0.81，95%CI：0.70，0.94）、女性乳腺癌（HR0.85，95%CI：0.77，0.94）、肝胆道癌（HR0.72，95%CI：0.53，0.97）和结肠癌（HR0.86，95%CI：0.74，0.99）发病风险降低相关。中身体活动水平与较低的口咽癌（HR0.71，95%CI：0.55，0.93）和肺癌（HR0.86，95%CI：0.74，0.99）发病风险降低相关，与低身体活动水平相比。敏感性分析显示，较高的身体活动与较低的食管癌和较高的前列腺癌发病风险相关。
有规律的身体活动与降低肺癌、乳腺癌、肝胆道癌、结肠癌和口咽癌的发病风险显著相关。我们的研究结果强调了促进身体活动，特别是高水平身体活动，在癌症预防中的重要性。
