Khidri Feriha F, Shaikh Fozia, Khowaja Imran-Ul-Hassan, Riaz Hina
Department of Biochemistry, Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
Biochemistry Department, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Curr Hypertens Rev. 2020;16(3):223-228. doi: 10.2174/1573402116666200720001032.
Pre-eclampsia is a hypertensive pregnancy disorder accompanied by proteinuria. Serum Lactate Dehydrogenase (LDH) is a biochemical marker that reflects the severity and progression of pre-eclampsia.
A cross-sectional study was conducted at the Liaquat University of Medical and Health Sciences (LUMHS). One hundred pre-eclamptic women were enrolled and categorized into mild (n=30) and severe pre-eclamptic groups (n=70) to ascertain the function of LDH as a prognostic marker and to assess its association with severity and gestational age in pre-eclamptic women.
The significant differences in mean concentrations of LDH between mild and severe preeclamptic women (p-value <0.0001) and early and late-onset pre-eclamptic women (p-value=0.049) were found. Significant differences were also found in the LDH range between mild and severe preeclamptic women presented with late-onset pre-eclampsia (p-value= 0.004). Statistically significant differences (p-value= 0.019) in the levels of LDH were found with systolic blood pressure and proteinuria (p-value= 0.048).
LDH is the prognostic marker representing the severity of pre-eclampsia. An increased level of LDH directs adequate monitoring and management; and by early detection of preeclampsia, serious consequences and complications may be prevented.
子痫前期是一种伴有蛋白尿的妊娠高血压疾病。血清乳酸脱氢酶（LDH）是一种反映子痫前期严重程度和进展的生化标志物。
在利亚卡特医科和健康科学大学（LUMHS）进行了一项横断面研究。招募了100名单纯性高血压孕妇，并将其分为轻度（n = 30）和重度子痫前期组（n = 70），以确定LDH作为预后标志物的功能，并评估其与子痫前期孕妇严重程度和孕周的关系。
发现轻度和重度子痫前期孕妇（p值<0.0001）以及早发型和晚发型子痫前期孕妇（p值 = 0.049）的LDH平均浓度存在显著差异。在出现晚发型子痫前期的轻度和重度子痫前期孕妇之间，LDH范围也存在显著差异（p值 = 0.004）。发现LDH水平与收缩压（P值 = 0.019）和蛋白尿（P值 = 0.048）存在统计学显著差异。
LDH是代表子痫前期严重程度的预后标志物。LDH水平升高指导进行充分的监测和管理；通过早期发现子痫前期，可以预防严重后果和并发症。
