Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China.
School of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
Hum Immunol. 2020 Aug;81(8):445-451. doi: 10.1016/j.humimm.2020.07.002. Epub 2020 Jul 16.
Proteasome subunit beta types 8 and 9 (PSMB8, PSMB9) play critical roles in the human leukocyte antigen class I (HLA I)-presenting system. Studies have suggested that polymorphisms in the PSMB8 and PSMB9 genes may influence the immune functions of PSMB8 and PSMB9, and thus be associated with various human cancers. We investigated associations involving single nucleotide polymorphisms (SNPs) rs2071543 in PSMB8, rs1351383, rs17587 and rs2127675 in PSMB9 and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer in a Chinese Han population. A total of 543 patients with CIN, 1008 patients with cervical cancer, and 1120 healthy individuals were enrolled. Agena MassArray was used for SNP genotyping of PSMB8 and PSMB9. Associations involving these SNPs and risk of CIN and cervical cancer were analysed. Our results showed that the PSMB8 T/T and T/G genotypes of rs2071543 may be associated with a higher risk of CIN (P = 0.011, OR = 1.35,95% CI: 1.07-1.70) and cervical cancer (P = 0.006, OR = 1.31, 95% CI: 1.08-1.59). For rs17587, the A allele (P = 0.001, OR = 1.303, 95% CI: 1.115-1.522), and the A/A and A/G genotypes (P = 0.001, OR = 1.36, 95% CI: 1.13-1.63) may be risk factors for cervical cancer. These results indicated that PSMB8 rs2071543 might influence susceptibility to CIN and cervical cancer, and PSMB9 rs17587 might influence cervical cancer susceptibility in a Chinese Han population.
蛋白酶体亚基β类型 8 和 9（PSMB8、PSMB9）在人类白细胞抗原 I 类（HLA I）呈递系统中发挥关键作用。研究表明，PSMB8 和 PSMB9 基因中的多态性可能影响 PSMB8 和 PSMB9 的免疫功能，从而与各种人类癌症相关。我们在中国汉族人群中研究了 PSMB8 中的单核苷酸多态性（SNP）rs2071543、PSMB9 中的 rs1351383、rs17587 和 rs2127675 与宫颈上皮内瘤变（CIN）和宫颈癌风险的关联。共纳入 543 例 CIN 患者、1008 例宫颈癌患者和 1120 名健康对照者。使用 Agena MassArray 对 PSMB8 和 PSMB9 的 SNP 进行基因分型。分析了这些 SNP 与 CIN 和宫颈癌风险的关系。我们的结果表明，PSMB8 rs2071543 的 T/T 和 T/G 基因型可能与 CIN（P = 0.011，OR = 1.35，95%CI：1.07-1.70）和宫颈癌（P = 0.006，OR = 1.31，95%CI：1.08-1.59）的风险增加相关。对于 rs17587，A 等位基因（P = 0.001，OR = 1.303，95%CI：1.115-1.522）和 A/A 和 A/G 基因型（P = 0.001，OR = 1.36，95%CI：1.13-1.63）可能是宫颈癌的危险因素。这些结果表明，PSMB8 rs2071543 可能影响 CIN 和宫颈癌的易感性，PSMB9 rs17587 可能影响中国汉族人群宫颈癌的易感性。
