Ibn Tofaïl University - CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), 14000 Kenitra, Morocco.
Research Team in Neurology and Neurogenetics, Genomics Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed 5th University, 10100 Rabat, Morocco.
J Nutr Sci. 2020 Jun 30;9:e24. doi: 10.1017/jns.2020.18. eCollection 2020.
Obese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in the gene plays a significant role in this pathway. We assessed the association between the orosensory detection of a long-chain fatty acid, i.e. oleic acid (OA), and genetic polymorphism of the lipid taste sensor CD36 in obese and normal-weight subjects. Adult participants were recruited in the fasting condition. They were invited to fat taste perception sessions, using emulsions containing OA and according to the three-alternative forced-choice (3-AFC) method. Genomic DNA was used to determine the polymorphism (SNP rs 1761667) of the gene. Obese ( 50; BMI 34⋅97 (sd 4⋅02) kg/m) exhibited a significantly higher oral detection threshold for OA (3⋅056 (sd 3⋅53) mmol/l) than did the normal-weight ( 50; BMI 22⋅16 (sd 1⋅81) kg/m) participants (1⋅20 (sd 3⋅23) mmol/l; = 0⋅007). There was a positive correlation between OA detection thresholds and BMI in all subjects; evenly with body fat percentage (BF%). AA genotype was more frequent in the obese group than normal-weight group. OA detection thresholds were much higher for AA and AG genotypes in obese subjects compared with normal-weight participants. Higher oral detection thresholds for fatty acid taste are related to BMI, BF% and not always to genotype.
肥胖受试者表现出对膳食脂质的偏好。最近的一系列证据表明，基因中的一个变体在这一途径中起着重要作用。我们评估了长链脂肪酸（即油酸）的味觉感知与脂质味觉传感器 CD36 基因遗传多态性在肥胖和正常体重受试者之间的关联。成年参与者在禁食状态下被招募。他们被邀请参加脂肪味觉感知测试，使用含有 OA 的乳液，并根据三择一强制选择（3-AFC）方法。使用基因组 DNA 来确定基因（SNP rs 1761667）的多态性。肥胖组（50 人；BMI 34.97（标准差 4.02）kg/m）的 OA 口腔检测阈值（3.056（标准差 3.53）mmol/l）明显高于正常体重组（50 人；BMI 22.16（标准差 1.81）kg/m）（1.20（标准差 3.23）mmol/l；= 0.007）。在所有受试者中，OA 检测阈值与 BMI 呈正相关；与体脂肪百分比（BF%）均匀相关。AA 基因型在肥胖组中的频率高于正常体重组。与正常体重参与者相比，肥胖受试者的 OA 检测阈值对于 AA 和 AG 基因型更高。脂肪酸味觉的口腔检测阈值较高与 BMI 和 BF%相关，而不一定与基因型相关。
