Ziaei Samaneh, Joni Saeid Sadeghi, Shahriar Reza, Shahzamani Mehran
DDS, MS. Assistant Professor, Dept. of Dral and Maxillofacial Medicine, Faculty of Dentistry, Sharekord Branch Shahrekord, Iran.
Department of Radiology, Razi Hospital, Guilan University of Medical Sciences Rasht, Iran.
Am J Blood Res. 2020 Jun 15;10(3):46-51. eCollection 2020.
Mastoidectomy is one of the important head and neck surgeries which is mostly performed due to complications of otitis media. This procedure is performed under microscopic surgery and as a result, a clean visual field is required for surgeons. Bleeding is one of the important issues during microscopic surgeries which reduces visualization. In this clinical trial, we aimed to examine effects of tranexamic acid in reducing bleeding during mastoidectomy. Here we investigated 69 patients who were candidates of mastoidectomy. Patients were randomized into two groups. In group 1, patients received tranexamic acid (10 mg/kg) at the beginning of surgeries along with other anesthetic drugs. In group 2, patients received normal saline as placebo with the same volume. Data regarding to bleeding, duration of surgeries, heart rate and blood pressure of patients were collected and analyzed. We indicated that administration of tranexamic acid is associated with significant reduced bleeding and also reduced blood pressure during surgeries (P<0.001). Taken together, we suggest that otolaryngologists should administer tranexamic acid during microscopic surgeries in order to reduce bleeding and provide a better visual field.
乳突切除术是重要的头颈外科手术之一，主要因中耳炎并发症而进行。该手术在显微镜下进行，因此外科医生需要清晰的视野。出血是显微手术中的重要问题之一，会降低视野清晰度。在这项临床试验中，我们旨在研究氨甲环酸在减少乳突切除术中出血方面的效果。我们调查了69例拟行乳突切除术的患者。患者被随机分为两组。第1组患者在手术开始时与其他麻醉药物一起接受氨甲环酸（10mg/kg）。第2组患者接受相同体积的生理盐水作为安慰剂。收集并分析了患者的出血情况、手术时长、心率和血压数据。我们发现，使用氨甲环酸与手术中出血显著减少以及血压降低有关（P<0.001）。综上所述，我们建议耳鼻喉科医生在显微手术中使用氨甲环酸，以减少出血并提供更好的视野。
