Department of Otolaryngology Head & Neck Surgery, Hôpital Fondation Rothschild, Paris, France.
J Int Adv Otol. 2024 Mar 27;20(2):175-181. doi: 10.5152/iao.2024.231275.
Tranexamic acid is an antifibrinolytic agent widely used in several surgical procedures to reduce intraoperative bleeding. Intraoperative bleeding is a crucial problem for the ear surgeon, as it prevents good visualization of the surgical field. The aim of this work was to analyze the relevant literature about the use of tranexamic acid in ear surgery. A literature search was conducted in agreement with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, across 3 databases (Medline, Cochrane, and Google Scholar), with the terms "tranexamic acid," and "ear," and "surgery." Three prospective, randomized, and double-blind clinical trials met the inclusion criteria. Studies were not able to be pooled because of heterogeneity in material, methods of delivery and evaluation, and procedures used. Despite these limitations, all 3 papers found a significant reduction in intraoperative bleeding, allowing a better visualization of the operating field. Despite the scarcity of published trials, tranexamic acid is safe and seems to be useful in reducing intraoperative bleeding in ear surgery, thus improving operative field visualization.
氨甲环酸是一种抗纤维蛋白溶解剂，广泛用于多种外科手术中，以减少术中出血。术中出血是耳科医生面临的一个关键问题，因为它会妨碍手术视野的良好观察。本研究旨在分析氨甲环酸在耳科手术中的应用相关文献。按照系统评价和荟萃分析的 Preferred Reporting Items（PRISMA）2020 声明，在 3 个数据库（Medline、Cochrane 和 Google Scholar）中进行了文献检索，使用的术语是“tranexamic acid”和“ear”和“surgery”。符合纳入标准的有 3 项前瞻性、随机、双盲临床试验。由于材料、给药和评估方法以及使用的程序存在异质性，研究无法进行汇总。尽管存在这些局限性，但所有 3 篇论文都发现术中出血明显减少，从而可以更好地观察手术视野。尽管发表的试验数量有限，但氨甲环酸安全且似乎有助于减少耳科手术中的术中出血，从而改善手术视野。
