TGF-β 信号在心肌细胞增殖中的作用。
The Role of TGF-β Signaling in Cardiomyocyte Proliferation.
机构信息
Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.
出版信息
Curr Heart Fail Rep. 2020 Oct;17(5):225-233. doi: 10.1007/s11897-020-00470-2.
Abstract
PURPOSE OF REVIEW
The loss of contractile function after heart injury remains one of the major healthcare issues of our time. One strategy to deal with this problem would be to increase the number of cardiomyocytes to enhance cardiac function. In the last couple of years, reactivation of cardiomyocyte proliferation has repeatedly demonstrated to aid in functional recovery after cardiac injury.
RECENT FINDINGS
The Tgf-β superfamily plays key roles during development of the heart and populating the embryonic heart with cardiomyocytes. In this review, we discuss the role of Tgf-β signaling in regulating cardiomyocyte proliferation during development and in the setting of cardiac regeneration. Although various pathways to induce cardiomyocyte proliferation have been established, the extent to which cardiomyocyte proliferation requires or involves activation of the Tgf-β superfamily is not entirely clear. More research is needed to better understand cross-talk between pathways that regulate cardiomyocyte proliferation.
摘要
目的综述
心肌损伤后收缩功能的丧失仍然是当前医疗保健的主要问题之一。解决这一问题的策略之一是增加心肌细胞的数量以增强心脏功能。在过去的几年中，心肌细胞增殖的再激活已被反复证明有助于心脏损伤后的功能恢复。
最近的发现
TGF-β 超家族在心脏发育和胚胎心脏的心肌细胞生成中起着关键作用。在这篇综述中，我们讨论了 TGF-β 信号在心脏发育过程中以及在心脏再生过程中调节心肌细胞增殖的作用。尽管已经建立了各种诱导心肌细胞增殖的途径，但心肌细胞增殖在多大程度上需要或涉及 TGF-β 超家族的激活尚不完全清楚。需要进一步的研究来更好地理解调节心肌细胞增殖的途径之间的相互作用。
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