Bois Axelle, Grandela Catarina, Gallant James, Mummery Christine, Menasché Philippe
Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Department of Cardiovascular Surgery, Université Paris Cité, INSERM U970, PARCC Hôpital Européen Georges Pompidou, 75015, Paris, France.
NPJ Regen Med. 2025 Jan 22;10(1):6. doi: 10.1038/s41536-025-00394-2.
Myocardial infarction (MI) causes the loss of millions of cardiomyocytes, and current treatments do not address this root issue. New therapies focus on stimulating cardiomyocyte division in the adult heart, inspired by the regenerative capacities of lower vertebrates and neonatal mice. This review explores strategies for heart regeneration, offers insights into cardiomyocyte proliferation, evaluates in vivo models, and discusses integrating in vitro human cardiac models to advance cardiac regeneration research.
心肌梗死（MI）导致数百万心肌细胞丧失，而目前的治疗方法并未解决这一根本问题。受低等脊椎动物和新生小鼠再生能力的启发，新的治疗方法聚焦于刺激成年心脏中的心肌细胞分裂。本综述探讨了心脏再生的策略，深入分析了心肌细胞增殖情况，评估了体内模型，并讨论了整合体外人类心脏模型以推动心脏再生研究。
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