Department of Neuroscience, University of Padova, Padova, Italy.
Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy.
J Peripher Nerv Syst. 2020 Sep;25(3):212-221. doi: 10.1111/jns.12405. Epub 2020 Aug 7.
The peripheral nervous system may be involved at any stage in the course of several hematological diseases, the most common being monoclonal gammopathies (of undetermined significance or malignant) or lymphomas. The underlying pathogenic mechanisms are different and therapies aim at targeting the dangerous either B-cell or plasma cell clones. Recently, high-throughput technologies, and next-generation sequencing have increased our knowledge of hematological diseases pathogenesis by the identification of somatic mutation affecting pivotal signaling pathways. Accordingly, new target therapies are used that may also be borrowed for treatment of neuropathies in hematological diseases.
周围神经系统可能在几种血液系统疾病的任何阶段受到累及，最常见的是单克隆丙种球蛋白病（意义未明或恶性）或淋巴瘤。潜在的发病机制不同，治疗旨在针对危险的 B 细胞或浆细胞克隆。最近，高通量技术和下一代测序通过鉴定影响关键信号通路的体细胞突变，增加了我们对血液系统疾病发病机制的认识。因此，正在使用新的靶向治疗方法，这些方法也可能被用于治疗血液系统疾病相关的神经病变。
