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血液系统疾病相关神经病变中神经损伤的机制:来自神经活检的经验教训

Mechanisms of Nerve Damage in Neuropathies Associated with Hematological Diseases: Lesson from Nerve Biopsies.

作者信息

Briani Chiara, Ferrari Sergio, Campagnolo Marta, Tagliapietra Matteo, Castellani Francesca, Salvalaggio Alessandro, Mariotto Sara, Visentin Andrea, Cavallaro Tiziana

机构信息

Department of Neurosciences, University of Padova, 35100 Padova, Italy.

Neurology Unit, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.

出版信息

Brain Sci. 2021 Jan 20;11(2):132. doi: 10.3390/brainsci11020132.

Abstract

Despite the introduction of non-invasive techniques in the study of peripheral neuropathies, sural nerve biopsy remains the gold standard for the diagnosis of several neuropathies, including vasculitic neuropathy and neurolymphomatosis. Besides its diagnostic role, sural nerve biopsy has helped to shed light on the pathogenic mechanisms of different neuropathies. In the present review, we discuss how pathological findings helped understand the mechanisms of polyneuropathies complicating hematological diseases.

摘要

尽管在外周神经病变的研究中引入了非侵入性技术,但腓肠神经活检仍然是诊断多种神经病变(包括血管炎性神经病变和神经淋巴瘤病)的金标准。除了其诊断作用外,腓肠神经活检还有助于阐明不同神经病变的发病机制。在本综述中,我们讨论了病理结果如何有助于理解血液系统疾病并发多发性神经病变的机制。

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