Department of Anatomy, School of Medicine, Chosun University, Gwangju, Republic of Korea.
Department of Ophthalmology, School of Medicine, Chosun University, Gwangju, Republic of Korea.
Eur J Ophthalmol. 2021 Jul;31(4):1915-1919. doi: 10.1177/1120672120944801. Epub 2020 Jul 18.
To investigate aqueous humor (AH) and serum levels of brain-derived neurotrophic factor (BDNF) in non-proliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME).
The prospective study consists of 20 patients with DME NPDR, 20 patients with no-DME NPDR, and 20 healthy control subjects. Serum and AH samples were obtained during cataract surgery and intravitreal injection. Serum and AH levels of BDNF were measured by enzyme-linked immunosorbent assay.
The mean serum levels of BDNF were lower in both NPDR groups compared to the control group (DME NPDR group, = 0.015; no-DME NPDR group, = 0.024). Furthermore, the mean serum level of BDNF was lower in the DME NPDR group compared to the no-DME NPDR group ( = 0.041). The mean AH levels of BDNF were significantly reduced in both NPDR groups compared to the control group (DME NPDR group, < 0.001; no-DME NPDR group, = 0.006). Further, the mean AH level of BDNF was significantly lower in the DME NPDR group compared to the no-DME NPDR group ( = 0.037).
Serum and AH levels of BDNF were reduced in NPDR patients with DME than without DME.
研究糖尿病性黄斑水肿（DME）伴非增生性糖尿病性视网膜病变（NPDR）患者房水中和血清中脑源性神经营养因子（BDNF）的水平。
本前瞻性研究纳入了 20 名 DME-NPDR 患者、20 名无 DME-NPDR 患者和 20 名健康对照者。在白内障手术和玻璃体内注射期间采集血清和房水样本。采用酶联免疫吸附试验测定血清和房水中 BDNF 的水平。
与对照组相比，两组 NPDR 患者的血清 BDNF 平均水平均较低（DME-NPDR 组， = 0.015；无 DME-NPDR 组， = 0.024）。此外，DME-NPDR 组的血清 BDNF 平均水平较无 DME-NPDR 组更低（ = 0.041）。与对照组相比，两组 NPDR 患者的房水中 BDNF 平均水平均显著降低（DME-NPDR 组， < 0.001；无 DME-NPDR 组， = 0.006）。此外，DME-NPDR 组的房水中 BDNF 平均水平显著低于无 DME-NPDR 组（ = 0.037）。
与无 DME-NPDR 患者相比，DME 伴 NPDR 患者的血清和房水中 BDNF 水平降低。
