首发非情感性精神病患者的十年认知进程：PAFIP队列研究
Ten-year course of cognition in first-episode non-affective psychosis patients: PAFIP cohort.
作者信息
Rodríguez-Sánchez José Manuel, Setién-Suero Esther, Suárez-Pinilla Paula, Mayoral Van Son Jaqueline, Vázquez-Bourgon Javier, Gil López Patxi, Crespo-Facorro Benedicto, Ayesa-Arriola Rosa
机构信息
Red de Salud Mental de Bizkaia. Biocruces Bizkaia Health Research Institute, Plaza de Cruces 12 48903, Barakaldo, Bizkaia, España.
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain.
出版信息
Psychol Med. 2022 Mar;52(4):770-779. doi: 10.1017/S0033291720002408. Epub 2020 Jul 20.
BACKGROUND
A large body of research states that cognitive impairment in schizophrenia is static. Nevertheless, most previous studies lack a control group or have small study samples or short follow-up periods.
METHOD
We aimed to address these limitations by studying a large epidemiological cohort of patients with first-episode schizophrenia spectrum disorders and a comparable control sample for a 10-year period.
RESULTS
Our results support the generalized stability of cognitive functions in schizophrenia spectrum disorders considering the entire group. However, the existence of a subgroup of patients characterized by deteriorating cognition and worse long-term clinical outcomes must be noted. Nevertheless, it was not possible to identify concomitant factors or predictors of deterioration (all Ps > 0.05).
CONCLUSIONS
Cognitive functions in schizophrenia spectrum disorder are stable; however, a subgroup of subjects that deteriorate can be characterized.
背景
大量研究表明精神分裂症的认知障碍是静态的。然而，以前的大多数研究缺乏对照组，或研究样本较小，或随访期较短。
方法
我们旨在通过对一大群首发精神分裂症谱系障碍患者和一个可比的对照样本进行为期10年的研究来解决这些局限性。
结果
考虑到整个群体，我们的结果支持精神分裂症谱系障碍中认知功能的普遍稳定性。然而，必须注意到存在一个以认知功能恶化和长期临床结果较差为特征的患者亚组。尽管如此，无法确定恶化的伴随因素或预测因素（所有P>0.05）。
结论
精神分裂症谱系障碍中的认知功能是稳定的；然而，可以对一个认知功能恶化的亚组进行特征描述。
Zotero 插件