Sevilla-Ramos Manuel, Ladera Valentina, García-García Ricardo, Crespo-Facorro Benedicto, Ayesa-Arriola Rosa
Faculty of Psychology, University of Salamanca, Salamanca, Spain.
Department of Psychiatry, Hospital Universitario Virgen del Rocío, University of Sevilla, Sevilla, Spain.
Eur Arch Psychiatry Clin Neurosci. 2024 Nov 6. doi: 10.1007/s00406-024-01937-2.
This study aimed to examine longitudinal changes in motor dexterity (MD) performance in first episode of psychosis (FEP), focusing on diagnosis-specific trajectories. Participants were recruited from the project PAFIP in Spain (134 FEP, 84 HC). MD was assessed using the Grooved Pegboard Test at baseline and at 10-year follow-up. Clinical and premorbid data were collected for the patients. FEP participants were classified as having schizophrenia (SCZ) or other psychosis (OP) and compared with a group of healthy controls (HC). MD correlated significantly with age and intelligence in all participants. MD in SCZ patients was additionally correlated with premorbid adjustment and negative symptoms, whereas in the OP group the association was with antipsychotic dose. SCZ patients showed a slight decline in MD at follow-up, whereas the OP and HC groups remained stable. There may be different long-term trajectories of MD across diagnoses in FEP patients. Early developmental factors such as premorbid adaptation and cognitive function, together with age-related changes, may influence a mild decline in MD specifically in schizophrenia.
本研究旨在考察首次发作精神病（FEP）患者运动敏捷性（MD）表现的纵向变化，重点关注特定诊断轨迹。参与者来自西班牙的PAFIP项目（134例FEP患者，84例健康对照）。在基线和10年随访时使用凹槽钉板测试评估MD。收集患者的临床和病前数据。FEP参与者被分类为患有精神分裂症（SCZ）或其他精神病（OP），并与一组健康对照（HC）进行比较。在所有参与者中，MD与年龄和智力显著相关。SCZ患者的MD还与病前适应和阴性症状相关，而在OP组中，这种关联与抗精神病药物剂量有关。随访时SCZ患者的MD略有下降，而OP组和HC组保持稳定。FEP患者不同诊断的MD可能存在不同的长期轨迹。病前适应和认知功能等早期发育因素，以及与年龄相关的变化，可能会影响MD的轻度下降，尤其是在精神分裂症患者中。
