MR Neuroimaging Agents, MPI for Biological Cybernetics, Tuebingen, Germany.
Chem Commun (Camb). 2020 Aug 19;56(66):9433-9436. doi: 10.1039/d0cc04416d.
We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(iii) chelates, able to generate a quantitative 19F MRI signal, while in parallel capable of modulating the 1H MRI signal in response to the coordination of Ca2+ ions. Subsequently, we performed experiments in vivo and estimated the concentration of the applied probe in the tissue by means of 19F MRI.
我们开发了一种基于纳米级全氟碳的系统，其中包含了顺磁 Gd(iii) 螯合物，能够产生定量的 19F MRI 信号，同时能够响应 Ca2+ 离子的配位来调节 1H MRI 信号。随后，我们进行了体内实验，并通过 19F MRI 来估计组织中应用探针的浓度。
