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可裂解β-环糊精纳米胶囊包载钆（III）螯合物作为响应型 MRI 探针。

Cleavable β-cyclodextrin nanocapsules incorporating Gd(III)-chelates as bioresponsive MRI probes.

机构信息

Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale Amedeo Avogadro, Viale T. Michel 11, 15121 Alessandria, Italy.

出版信息

Chem Commun (Camb). 2011 Mar 21;47(11):3144-6. doi: 10.1039/c0cc05428c. Epub 2011 Jan 26.

DOI:10.1039/c0cc05428c
PMID:21270985
Abstract

Perthiolated β-cyclodextrin-based nanocapsules incorporating diaquo Gd(III)-complexes represent a promising new type of bioresponsive MRI contrast agent, showing a pronounced relaxivity change upon degradation in a reducing environment.

摘要

载双水合 Gd(III)-配合物的季戊四醇-β-环糊精纳米胶囊是一种很有前途的新型生物响应性 MRI 对比剂，在还原环境中降解时表现出明显的弛豫率变化。

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