Department of Materials Science & Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
School of Chemistry and Environmental Engineering, Shanxi Datong University, Datong 037009, P. R. China.
Biomacromolecules. 2020 Sep 14;21(9):3512-3522. doi: 10.1021/acs.biomac.0c00530. Epub 2020 Aug 4.
An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol-ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed excellent flexibility as well as torsion resistance. Antibacterial efficacy of hydrogels (and degradation products) was evaluated using (Gram-negative) and (Gram-positive). Efficacy was found to increase with the concentration of cetyl chloroacetate (CCA) in the hydrogel network, reaching 93% and 99% for and , respectively. Degradation of hydrogels was observed in weak alkali conditions (pH = 8) and at physiological conditions (pH = 7.4). The degradation time of the hydrogels could be finely tuned by variation of the CCA content in the hydrogel and environmental stimulus. The tunable degradation behavior under physiological conditions combined with high antibacterial efficacy could render the presented materials interesting for tissue engineering applications.
通过高效的硫醇-烯和曼尼希点击反应，开发了一种合成含有八倍半硅氧烷（POSS）的可降解水凝胶的有效方法。水凝胶的屈服强度为 0.36 MPa，压缩模量为 4.38 MPa，具有优异的柔韧性和抗扭强度。通过（革兰氏阴性菌）和（革兰氏阳性菌）评估水凝胶（及其降解产物）的抗菌功效。发现抗菌功效随水凝胶网络中氯乙酰基十六烷基酯（CCA）的浓度增加而增加，对 和 的抑菌率分别达到 93%和 99%。在弱碱性条件（pH = 8）和生理条件（pH = 7.4）下观察到水凝胶的降解。水凝胶的降解时间可以通过水凝胶中 CCA 含量和环境刺激的变化进行精细调节。在生理条件下的可调降解行为与高抗菌功效相结合，使得所提出的材料在组织工程应用中具有吸引力。
