Presentato Alessandro, La Greca Eleonora, Consentino Luca, Alduina Rosa, Liotta Leonarda Francesca, Gruttadauria Michelangelo
Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Viale Delle Scienze, Edificio 17, I-90128 Palermo, Italy.
Istituto per lo Studio dei Materiali Nanostrutturati (ISMN)-CNR, Via Ugo La Malfa 153, I-90146 Palermo, Italy.
Nanomaterials (Basel). 2023 Apr 6;13(7):1291. doi: 10.3390/nano13071291.
The reaction of octakis(3-chloropropyl)octasilsesquioxane with four equivalents of 1-hexylimidazole or 1-decylimidazole gave two products labelled as HQ-POSS (hexyl-imidazolium quaternized POSS) and DQ-POSS (decyl-imidazolium quaternized POSS) as regioisomer mixtures. An investigation of the biological activity of these two compounds revealed the higher antimicrobial performances of HQ-POSS against Gram-positive and Gram-negative microorganisms, proving its broad-spectrum activity. Due to its very viscous nature, HQ-POSS was adsorbed in variable amounts on the surface of biologically active oxides to gain advantages regarding the expendability of such formulations from an applicative perspective. Titania and 5 wt% Cu on titania were used as supports. The materials 10HQ-POSS/Ti and 15HQ-POSS/5CuTi strongly inhibited the ability of PS27 cells-a bacterial strain described for its ability to handle very toxic organic solvents and perfluorinated compounds-to grow as planktonic cells. Moreover, the best formulations (i.e., 10HQ-POSS/Ti and 15HQ-POSS/5CuTi) could prevent PS27 biofilm formation at a certain concentration (250 μg mL) which greatly impaired bacterial planktonic growth. Specifically, 15HQ-POSS/5CuTi completely impaired cell adhesion, thus successfully prejudicing biofilm formation and proving its suitability as a potential antifouling agent. Considering that most studies deal with quaternary ammonium salts (QASs) with long alkyl chains (>10 carbon atoms), the results reported here on hexylimidazolium-based POSS further deepen the knowledge of QAS formulations which can be used as antifouling compounds.
八（3 - 氯丙基）倍半硅氧烷与四当量的1 - 己基咪唑或1 - 癸基咪唑反应，生成了两种标记为HQ - POSS（己基咪唑鎓季铵化倍半硅氧烷）和DQ - POSS（癸基咪唑鎓季铵化倍半硅氧烷）的区域异构体混合物。对这两种化合物的生物活性研究表明，HQ - POSS对革兰氏阳性和革兰氏阴性微生物具有更高的抗菌性能，证明了其广谱活性。由于其非常粘稠的性质，HQ - POSS以不同量吸附在生物活性氧化物表面，从应用角度来看，这样做能在制剂的使用便利性方面获得优势。二氧化钛和负载5 wt%铜的二氧化钛用作载体。材料10HQ - POSS/Ti和15HQ - POSS/5CuTi强烈抑制了PS27细胞（一种因其能够处理剧毒有机溶剂和全氟化合物的能力而被描述的细菌菌株）作为浮游细胞生长的能力。此外，最佳制剂（即10HQ - POSS/Ti和15HQ - POSS/5CuTi）在一定浓度（250 μg/mL）下可以防止PS27生物膜形成，这极大地损害了细菌浮游生长。具体而言，15HQ - POSS/5CuTi完全抑制了细胞粘附，从而成功阻碍了生物膜形成，并证明了其作为潜在防污剂的适用性。考虑到大多数研究涉及具有长烷基链（>10个碳原子）的季铵盐（QASs），这里报道的关于基于己基咪唑鎓的倍半硅氧烷的结果进一步加深了对可作为防污化合物的QAS制剂的认识。
