Department of Biomedical Engineering, College of Engineering, Peking University, 100871 Beijing, China.
MOE Key Laboratory of Bioinformatics, Bioinformatics Division, Center for Synthetic & Systems Biology, BNRist, Center for Synthetic & Systems Biology, Tsinghua University, 100084 Beijing, China; Department of Automation, Tsinghua University, 100084 Beijing, China.
Micron. 2020 Oct;137:102916. doi: 10.1016/j.micron.2020.102916. Epub 2020 Jul 15.
Super-resolution microscopy can reveal the subtle biological processes hidden behind the optical diffraction barrier. Plasmonics is a key nanophotonic that combines electronics and photonics through the interaction of light with the metallic nanostructure. In this review, we survey the recent progresses on plasmonic-assisted super-resolution microscopy. The strong electromagnetic field enhancement trapped near metallic nanostructures offers a unique opportunity to manipulate the illumination scheme for overcoming the diffraction limit. Plasmonic nanoprobes, exploited as surface-enhanced Raman scattering (SERS) and plasmon-enhanced fluorescence nanoparticles, are a major category of contrast agent in super-resolution microscopy. The outstanding challenges, future developments, and potential biological applications are also discussed.
超分辨率显微镜可以揭示隐藏在光学衍射障碍背后的微妙生物过程。等离子体学是一种关键的纳米光子学，通过光与金属纳米结构的相互作用将电子学和光子学结合在一起。在这篇综述中，我们调查了等离子体辅助超分辨率显微镜的最新进展。在金属纳米结构附近捕获的强电磁场增强提供了一个独特的机会来操纵照明方案，以克服衍射极限。等离子体纳米探针作为表面增强拉曼散射（SERS）和等离子体增强荧光纳米颗粒被广泛应用于超分辨率显微镜中的对比剂。本文还讨论了突出的挑战、未来的发展和潜在的生物学应用。
