Department of Pediatrics, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Clin Nutr ESPEN. 2020 Aug;38:277-279. doi: 10.1016/j.clnesp.2020.05.021. Epub 2020 Jun 27.
Congenital heart defects (CHDs) have been known as the most frequent kind of congenital disorders among all human congenital abnormalities all over the world. There has been a potential connection between the use of folic acid by mothers and an amelioration in the rate of offsprings being born with CHDs in future. In this article, we aimed to assess the strength of evidence related to folic acid intake in prevention of CHDs.
PubMed, Web of science, Scopus, ScienceDirect, and the Cochrane Library were searched up to October 2019 for publications involving the association between using folic acid and rate of CHDs.
The search strategy yielded 1223 potentially relevant articles. Reading the titles and abstracts was fulfilled after finishing the search of databases to identify appropriate articles for review of full texts of the publications. A total of 20 articles were finalized for full text analysis. No more publications were added to current study after the reference review of the included studies.
Based on the conducted studies, the effectiveness of folic acid alone on CHDs is still not fully clear and more comprehensive studies, well-designed trials with respect to well-defined CHDs, appropriate doses of folic acid, early onset of its prescription in a homogeneous population of nulliparous women without any history of abortions or stillbirths are needed to develop medical primary preventive measures for CHDs in future.
先天性心脏病（CHD）是全世界所有先天性异常中最常见的先天性疾病。母亲服用叶酸与降低后代 CHD 出生率之间存在潜在联系。本文旨在评估与叶酸摄入预防 CHD 相关的证据强度。
截至 2019 年 10 月，通过 PubMed、Web of science、Scopus、ScienceDirect 和 Cochrane Library 检索与叶酸使用和 CHD 发生率之间关联的出版物。
搜索策略产生了 1223 篇潜在相关文章。在完成数据库搜索以确定适合综述出版物全文分析的文章后，阅读了标题和摘要。最终有 20 篇文章进行了全文分析。在对纳入研究的参考文献进行审查后，没有更多的出版物添加到当前研究中。
基于已进行的研究，叶酸单独预防 CHD 的效果尚不清楚，需要进行更多全面的研究、设计良好的试验，明确 CHD 类型、叶酸的适当剂量、在没有流产或死产史的初产妇均质人群中尽早开始处方，以制定未来 CHD 的医疗一级预防措施。
