Wayal Sandesh R, Gurav Shailendra S
Center for Research and Development, PRIST University, Thanjavur, Tamilnadu, India.
Goa College of Pharmacy, Panaji, Goa, India.
J Ayurveda Integr Med. 2020 Jul-Sep;11(3):261-269. doi: 10.1016/j.jaim.2020.05.005. Epub 2020 Jul 17.
Ayurveda is primarily based upon use of herbs either singly or in combination (polyherbal). The cow ghee (clarified butterfat) is considered as a precious base for preparing medicines in Ayurveda. Processing of ghee with plant ingredients is renowned for enhancing their therapeutic efficacy.
In present research work, the attempt was made to develop cow ghee based Polyherbal Bhallatakadi Ghrita formulations and evaluate them with reference to 'Murcchana' and 'Shata-Dhauta' process.
The research plants were identified, procured, authenticated and processed. The extracts of plant materials were prepared and used for development of Polyherbal Bhallatakadi Ghrita (PHBG), Polyherbal Bhallatakadi Murcchita Ghrita and Polyherbal Bhallatakadi Shata-Dhauta Ghrita formulations as per Ayurvedic procedures. The prepared ghrita formulations were subjected to organoleptic (colour, odour, taste, appearance and touch), physicochemical (pH, viscosity, moisture content, specific gravity, refractive index, acid value, saponification value, iodine value, peroxide value, Rechert Meissl value and Polenske value) evaluation, in-vitro antioxidant and GC-MS analysis. The accelerated and real time stability studies were carried out to determine shelf life of ghrita formulations.
The results of evaluations indicate that, developed PHBG formulations retained the organoleptic and physicochemical characteristics of ghee. The shelf life of formulations was found to be in the range of 1.6 to 3.3 years at accelerated and 2.2 to 3.8 years at real time stability conditions. All ghrita formulations exhibited antioxidant activity in dose dependent manner.
The standardization or evaluation of Polyherbal Bhallatakadi Ghrita formulations was found to be crucial for the establishment of a steady biological, chemical or simply a quality assurance profile of the drugs.
阿育吠陀医学主要基于单独使用草药或草药组合（多草药配方）。在阿育吠陀医学中，牛酥油（澄清的黄油）被视为制备药物的珍贵基质。用植物成分加工酥油以提高其治疗功效而闻名。
在目前的研究工作中，尝试开发基于牛酥油的多草药跋罗陀迦底酥油制剂，并参照“昏沉”和“百次淘洗”工艺对其进行评估。
对研究用植物进行鉴定、采购、验证和加工。按照阿育吠陀程序制备植物材料提取物，并用于开发多草药跋罗陀迦底酥油（PHBG）、多草药跋罗陀迦底昏沉酥油和多草药跋罗陀迦底百次淘洗酥油制剂。对制备的酥油制剂进行感官（颜色、气味、味道、外观和触感）、理化（pH值、粘度、水分含量、比重、折射率、酸值、皂化值、碘值、过氧化值、雷氏-迈斯尔值和波兰斯基值）评估、体外抗氧化和气相色谱-质谱分析。进行加速和实时稳定性研究以确定酥油制剂的保质期。
评估结果表明，所开发的PHBG制剂保留了酥油的感官和理化特性。在加速条件下，制剂的保质期为1.6至3.3年，在实时稳定性条件下为2.2至3.8年。所有酥油制剂均呈现剂量依赖性抗氧化活性。
发现多草药跋罗陀迦底酥油制剂的标准化或评估对于建立药物稳定的生物学、化学或简单的质量保证概况至关重要。
