Gurav Nilambari, Gurav Shailendra, Wanjari Manish, Prasad Satyendra, Wayal Sandesh, Rarokar Nilesh
PES's Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa University, Goa, 403401 India.
Goa College of Pharmacy, Department of Pharmacognosy, Panaji, Goa University, Goa, 403 001 India.
J Ayurveda Integr Med. 2021 Apr-Jun;12(2):294-301. doi: 10.1016/j.jaim.2020.09.007. Epub 2020 Dec 17.
Ghee is widely considered as the Indian name for clarified butterfat and processing of ghee with therapeutic herbs i.e. ghrita is renowned for augmenting their medicinal properties. Kaamdev ghrita (also known as 'VajikaranaRasayana') is cow ghee based classical Ayurvedic formulation from the aphrodisiac category, which is used to ameliorate and potentiate sexual performance and also in the treatment of sexual dysfunctions, infertility, and premature ejaculation.
Present research work deals with the organoleptic, physicochemical, and biological assessment of Kaamdev ghrita for its aphrodisiac activity using in-vivo animal models.
Kaamdev ghrita was prepared using Indian cow's ghee as per standard Ayurvedic classical texts and subjected to organoleptic (color, odor, taste, texture, touch), physicochemical (acid value, peroxide value, iodine value, saponification value, unsaponifiable matter, extractive values, refractive index, and specific gravity) analyses as per the standard pharmacopeial procedures. The aphrodisiac potential of ghrita in rat model was evaluated by monitoring sexual behavioral performance using different parameters (mount frequency and latency, intromission frequency and latency, anogenital grooming and sniffing) at the dose of 150 and 300 mg/kg body weight.
The physicochemical evaluation of Kaamdev ghrita showed higher acid value, iodine value, refractive index, and specific gravity whereas the lower saponification and peroxide value than the plain ghee. Kaamdev ghrita revealed the presence of flavonoids, alkaloids, saponins, sterols, terpenoids, coumarins, tannins, and showed remarkable antioxidant activity by in-vitro assays. It augmented the sexual performance in a dose-dependent manner as indicated by significant improvement (P < 0.05) in mount frequency and latency, intromission frequency and latency, anogenital grooming, and sniffing as compared to plain ghee treated control group. The present investigation has corroborated the ethnopharmacological claim of Kaamdevghrita for its aphrodisiac potential.
Kaamdev ghrita exhibited aphrodisiac activity which may be attributed to the presence of antioxidant herbs present in it. It is the first scientific report on validation of the traditional claim of Kaamdev ghrita for its aphrodisiac potential.
酥油被广泛认为是澄清黄油脂肪的印度名称，用治疗性草药加工酥油，即酥醍醐，以增强其药用特性而闻名。卡姆德夫酥醍醐（也称为“VajikaranaRasayana”）是一种基于牛酥油的经典阿育吠陀配方，属于壮阳类药物，用于改善和增强性功能，也用于治疗性功能障碍、不孕症和早泄。
目前的研究工作涉及使用体内动物模型对卡姆德夫酥醍醐的壮阳活性进行感官、理化和生物学评估。
按照阿育吠陀经典文本的标准，用印度奶牛的酥油制备卡姆德夫酥醍醐，并按照标准药典程序进行感官（颜色、气味、味道、质地、触感）、理化（酸值、过氧化值、碘值、皂化值、不皂化物、提取物值、折射率和比重）分析。通过在150和300mg/kg体重剂量下监测不同参数（爬跨频率和潜伏期、插入频率和潜伏期、肛门生殖器梳理和嗅闻）的性行为表现，评估酥醍醐在大鼠模型中的壮阳潜力。
卡姆德夫酥醍醐的理化评估显示，其酸值、碘值、折射率和比重高于普通酥油，而皂化值和过氧化值低于普通酥油。卡姆德夫酥醍醐含有黄酮类、生物碱、皂苷、甾醇、萜类、香豆素、单宁，并通过体外试验显示出显著的抗氧化活性。与普通酥油处理的对照组相比，其爬跨频率和潜伏期、插入频率和潜伏期、肛门生殖器梳理和嗅闻均有显著改善（P<0.05），表明其以剂量依赖的方式增强了性功能。本研究证实了卡姆德夫酥醍醐壮阳潜力的民族药理学主张。
卡姆德夫酥醍醐表现出壮阳活性，这可能归因于其中存在的抗氧化草药。这是关于验证卡姆德夫酥醍醐壮阳潜力传统主张的第一份科学报告。
