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类风湿关节炎健康状况的稳定性:对确诊患者的五年研究

The stability of health status in rheumatoid arthritis: a five-year study of patients with established disease.

作者信息

Meenan R F, Kazis L E, Anderson J J

机构信息

Multipurpose Arthritis Center, Boston University School of Medicine, MA 02118.

出版信息

Am J Public Health. 1988 Nov;78(11):1484-7. doi: 10.2105/ajph.78.11.1484.

Abstract

We employed a health status measure to describe the outcomes of rheumatoid arthritis patients over five years. Of the 410 rheumatoid arthritis patients who were originally administered the Arthritis Impact Measurement Scales (AIMS), 299 completed a follow-up five years later. Data were analyzed using nine health status scales, three components of health status, and an overall arthritis impact item. Results for survivors indicated that there were no clinically important deteriorations in any of these measures. In fact, small improvements on most measures were found. The health status changes were similar for patients originally in a clinical trial and for those receiving routine specialty care. Age was found to positively relate to improvements in psychological status and overall arthritis impact, but we were unable to demonstrate any consistent effects of sex, marital status, education, or disease duration. Our results contrast with other studies that have noted major declines over time in the health status of patients with rheumatoid arthritis. Furthermore, level of education was not a major determinant of morbidity in this group. These results suggest that health status in certain patients with rheumatoid arthritis is more stable than previously thought. This has implications for both clinical practice and clinical research in rheumatology.

摘要

我们采用了一种健康状况测量方法来描述类风湿性关节炎患者五年后的病情转归。最初接受关节炎影响测量量表(AIMS)的410名类风湿性关节炎患者中,有299人在五年后完成了随访。使用九个健康状况量表、健康状况的三个组成部分以及一个总体关节炎影响项目对数据进行了分析。存活患者的结果表明,这些测量指标中没有任何一项出现具有临床意义的恶化。事实上,大多数测量指标都有小幅改善。最初参加临床试验的患者和接受常规专科护理的患者的健康状况变化相似。发现年龄与心理状态和总体关节炎影响的改善呈正相关,但我们未能证明性别、婚姻状况、教育程度或病程有任何一致的影响。我们的结果与其他研究形成对比,那些研究指出类风湿性关节炎患者的健康状况会随时间大幅下降。此外,教育程度不是该组发病率的主要决定因素。这些结果表明,某些类风湿性关节炎患者的健康状况比之前认为的更稳定。这对风湿病的临床实践和临床研究都有启示。

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本文引用的文献

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Outcome assessment in clinical trials. Evidence for the sensitivity of a health status measure.
Arthritis Rheum. 1984 Dec;27(12):1344-52. doi: 10.1002/art.1780271204.
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Formal education as a marker for increased mortality and morbidity in rheumatoid arthritis.
J Chronic Dis. 1985;38(12):973-84. doi: 10.1016/0021-9681(85)90095-5.
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