术前肿瘤活检比乳腺癌患者术中活检检测到更多的前哨淋巴结。

Preoperative tumor biopsy results in more detected sentinel nodes than intraoperative biopsy in breast cancer patients.

机构信息

School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250017, Shandong, People's Republic of China.

Department of Radiation Oncology, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, Yantai, 264000, Shandong, People's Republic of China.

出版信息

World J Surg Oncol. 2020 Jul 21;18(1):178. doi: 10.1186/s12957-020-01942-4.

DOI:10.1186/s12957-020-01942-4

PMID:32693797

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7374895/

Abstract

BACKGROUND

Sentinel lymph node biopsy (SLNB) plays a vital role in breast cancer surgery, and the identified number of sentinel nodes determines its accuracy for representing the status of the axillae. There are two types of tumor biopsies in breast cancer: preoperative and intraoperative biopsies. We compared the effects of the two different biopsies on the results of SLNB.

METHODS

Patients with clinical stages T1-3, N0 (cT1-3 N0) tumors were enrolled in this study. A total of 53% of patients received preoperative tumor biopsy, and 47% received intraoperative excisional biopsy. To identify the sentinel lymph nodes, patients received dual tracer injection. The number of SLNs detected and the false-negative rate were compared between groups.

RESULTS

A total of 204 patients were enrolled, 108 received preoperative tumor biopsy, and 96 received intraoperative excisional biopsy. Among all the patients, 160 received axillary lymph node dissection (ALND) following SLNB. Preoperative tumor biopsy detected more SLNs than intraoperative biopsy (mean rank 113.87 vs. 90.9, p = 0.004). The false-negative rates in the preoperative and intraoperative tumor biopsy groups were 3% and 18%, respectively.

CONCLUSIONS

Patients in the preoperative tumor biopsy group had more SLNs identified than intraoperative biopsy patients. The false-negative rate was also lower in the preoperative biopsy group.

摘要

背景

前哨淋巴结活检（SLNB）在乳腺癌手术中起着至关重要的作用，而识别到的前哨淋巴结数量决定了其对腋窝状态的代表性的准确性。乳腺癌有两种类型的肿瘤活检：术前活检和术中活检。我们比较了这两种不同活检对 SLNB 结果的影响。

方法

本研究纳入了临床分期为 T1-3、N0（cT1-3 N0）的肿瘤患者。共有 53%的患者接受了术前肿瘤活检，47%的患者接受了术中切除活检。为了识别前哨淋巴结，患者接受了双重示踪剂注射。比较两组之间检测到的前哨淋巴结数量和假阴性率。

结果

共纳入 204 例患者，108 例接受了术前肿瘤活检，96 例接受了术中切除活检。所有患者中，160 例在 SLNB 后接受了腋窝淋巴结清扫术（ALND）。术前肿瘤活检比术中活检检测到更多的前哨淋巴结（平均秩次 113.87 比 90.9，p = 0.004）。术前和术中肿瘤活检组的假阴性率分别为 3%和 18%。