Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju, 61005, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine, Daesingongwon 26, Seo-gu, Busan, 49201, Republic of Korea.
Sci Rep. 2020 Jul 21;10(1):12061. doi: 10.1038/s41598-020-69022-x.
Hemoglobin level determines blood viscosity and as hemoglobin level rises, blood pressure rises. However, hemoglobin level in individuals is not fixed and change in hemoglobin is affected by various clinical conditions. The purpose of this study is to investigate whether the hemoglobin variability affects the development of hypertension using Korean cohort database. This study was conducted with 94,798 adults (age ≥ 40 years) who visited the health screening in 2006 or 2007 (index year) and had at least 3 health screenings from 2002 to 2007. Hemoglobin variability was assessed by 3 indices of coefficient of variation (CV), standard deviation, and variability independent of the mean. Cox proportional hazard regression analysis was performed for each index of quartile groups (Q1-Q4). A total of 29,145 participants (30.7%) had the incidence of hypertension during a median follow-up of 7.4 ± 2.5 years. In the multivariable adjusted model, the hazard ratio and 95% confidence interval for incidence of hypertension of Q2, Q3, and Q4 compared with Q1 of hemoglobin variability CV were 1.014 [0.981-1.047], 1.064 [1.030-1.099] and 1.094 [1.059-1.131] respectively. The results were consistent in various sensitivity and subgroup analyses. This study showed that hemoglobin variability could be associated with hypertension development.
血红蛋白水平决定了血液的黏度，随着血红蛋白水平的升高，血压也会升高。然而，个体的血红蛋白水平并不是固定的，血红蛋白的变化受到各种临床情况的影响。本研究旨在使用韩国队列数据库探讨血红蛋白变异性是否会影响高血压的发生。本研究纳入了 94798 名年龄≥40 岁的成年人（2006 年或 2007 年[索引年份]接受健康筛查，并且在 2002 年至 2007 年期间至少进行了 3 次健康筛查）。血红蛋白变异性通过变异系数（CV）、标准差和均值独立变异的 3 个指数来评估。对每个四分位组（Q1-Q4）的指数进行 Cox 比例风险回归分析。在中位随访 7.4±2.5 年后，共有 29145 名参与者（30.7%）发生高血压。在多变量调整模型中，血红蛋白变异性 CV 的 Q2、Q3 和 Q4 组与 Q1 组相比，高血压发生率的风险比和 95%置信区间分别为 1.014[0.981-1.047]、1.064[1.030-1.099]和 1.094[1.059-1.131]。在各种敏感性和亚组分析中，结果都是一致的。本研究表明，血红蛋白变异性可能与高血压的发生有关。
