Probiotic treatment differentially affects the behavioral and electrophysiological aspects in ethanol exposed animals.

OBJECTIVES

Harmful effects of alcohol on brain function including cognitive phenomena are well known. Damage to gut microbiota is linked to neurological disorders. Evidence indicates that intestinal flora can be strengthened by probiotic bacteria. In this study, we evaluated the effect of probiotics administration on LTP induction in rats receiving ethanol.

MATERIALS AND METHODS

To assess if probiotic treatment influences toxic effect of ethanol, vehicle (CON) and probiotic treated (CON+PRO) control rats, and chronic ethanol (CE) exposed and CE probiotic treated (CE+PRO) animals were entered into the experiments. Shuttle box test and electrophysiological recordings were accomplished to evaluate memory and hippocampal baseline filed excitatory postsynaptic potentials (fEPSPs) and long term potentiation (LTP), respectively.

RESULTS

Ethanol impaired memory in the CE rats. It also diminished the slope size of fEPSPs and prevented LTP induction. While the probiotic supplementation improved memory in the CE+PRO rats, it did not influence synaptic transmission in these animals.

CONCLUSION

Conclusively, behavioral but not electrophysiological aspect of cognition is sensitive to probiotic treatment in the ethanol exposed animals.