Hadidi Zavareh Amir Hosein, Haji Khani Ramin, Pakpour Bahareh, Soheili Masoud, Salami Mahmoud
Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Biology, Faculty of Sciences Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Iran J Basic Med Sci. 2020 Jun;23(6):776-780. doi: 10.22038/ijbms.2020.41685.9846.
Harmful effects of alcohol on brain function including cognitive phenomena are well known. Damage to gut microbiota is linked to neurological disorders. Evidence indicates that intestinal flora can be strengthened by probiotic bacteria. In this study, we evaluated the effect of probiotics administration on LTP induction in rats receiving ethanol.
To assess if probiotic treatment influences toxic effect of ethanol, vehicle (CON) and probiotic treated (CON+PRO) control rats, and chronic ethanol (CE) exposed and CE probiotic treated (CE+PRO) animals were entered into the experiments. Shuttle box test and electrophysiological recordings were accomplished to evaluate memory and hippocampal baseline filed excitatory postsynaptic potentials (fEPSPs) and long term potentiation (LTP), respectively.
Ethanol impaired memory in the CE rats. It also diminished the slope size of fEPSPs and prevented LTP induction. While the probiotic supplementation improved memory in the CE+PRO rats, it did not influence synaptic transmission in these animals.
Conclusively, behavioral but not electrophysiological aspect of cognition is sensitive to probiotic treatment in the ethanol exposed animals.
酒精对脑功能包括认知现象的有害影响是众所周知的。肠道微生物群的损伤与神经疾病有关。有证据表明益生菌可增强肠道菌群。在本研究中，我们评估了给予益生菌对接受乙醇的大鼠长时程增强（LTP）诱导的影响。
为评估益生菌治疗是否影响乙醇的毒性作用，将溶剂对照组（CON）和益生菌治疗的对照组大鼠（CON+PRO），以及慢性乙醇暴露组（CE）和CE益生菌治疗组（CE+PRO）动物纳入实验。分别进行穿梭箱试验和电生理记录以评估记忆以及海马基线场兴奋性突触后电位（fEPSPs）和长时程增强（LTP）。
乙醇损害了CE组大鼠的记忆。它还减小了fEPSPs的斜率大小并阻止了LTP的诱导。虽然补充益生菌改善了CE+PRO组大鼠的记忆，但它并未影响这些动物的突触传递。
总之，在乙醇暴露的动物中，认知的行为方面而非电生理方面对益生菌治疗敏感。
