Department of Integrative Biology and Physiology, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Department of Integrative Biology and Physiology, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Trends Neurosci. 2018 Jul;41(7):413-414. doi: 10.1016/j.tins.2018.04.001.
The past decade has yielded substantial evidence that the gut microbiome modulates brain function, including for instance behaviors relevant to anxiety and depression, pointing to a need to identify the biological pathways involved. In 2013 Clarke and colleagues reported that the early-life microbiome regulates the hippocampal serotonergic system in a sex-dependent manner, findings that opened up numerous lines of inquiry on the effects of the microbiome on neurodevelopment and behavior.
过去十年的研究提供了大量证据表明，肠道微生物组可以调节大脑功能，包括与焦虑和抑郁等相关的行为，这表明需要确定涉及的生物学途径。2013 年，Clarke 及其同事报告称，早期生活微生物组以性别依赖的方式调节海马体 5-羟色胺能系统，这些发现为研究微生物组对神经发育和行为的影响开辟了许多研究途径。
