Presynaptic modulation by endogenous ouabain-like substances of noradrenaline release from blood vessels.
作者信息
Oberfrank F, Vizi E S, Lichtstein D
机构信息
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
出版信息
Pol J Pharmacol Pharm. 1988 Nov-Dec;40(6):685-90.
PMID:3269535
Abstract
The effect of an endogenous ouabain-like compound (OCL) and of ouabain was studied on [3H]noradrenaline release and on the tension of rabbit pulmonary arterial strip. Similarly to ouabain, the OLC enhanced release of [3H] NA in resting and in stimulated condition. Moreover, in the presence of OLC and ouabain, the tension of the rabbit artery increased gradually and the contraction evoked by electrical stimulation was potentiated. It is suggested that this mechanism might be involved in the physiological regulation of blood pressure or in the genesis of hypertension.
摘要
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